SARS CoV-2 Replication Attributed to Guanylate kinase 1: A SWOT Analysis

A recent interesting study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we argue that though this hypothesis might prove valid, GK 1 inhibitors are very unlikely, at least for the short term, to be beneficial in clinical management of COVID-19. However, we recommend conducting focused genetic studies to test their suggested hypothesis as it might add to our knowledge of some COVID-19 encountered idiosyncratic morbidity and mortality outcomes.