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Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner

Article scientifique 2021 Anglais

Résumé

Summary The Johnson and Johnson Ad26.COV2.S single dose vaccine represents an attractive option for COVID-19 vaccination in resource limited countries. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naïve with those either infected with the ancestral D614G virus, or infected in the second wave when Beta predominated. Prior infection significantly boosted spike binding antibodies, antibody-dependent cellular cytotoxicity and neutralizing antibodies against D614G, Beta and Delta, however neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses were induced after vaccination, regardless of prior infection. T cell recognition of variants was largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination following infection may result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern.

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Keeton, R., Richardson, S., Moyo-Gwete, T., Hermanus, T., Tincho, M., Benede, N., Manamela, N., Baguma, R., Makhado, Z., Ngomti, A., Motlou, T., Mennen, M., Chinhoyi, L., Skelem, S., Maboreke, H., Doolabh, D., Iranzadeh, A., Otter, A., Brooks, T., Noursadeghi, M., Moon, J., Grifoni, A., Weiskopf, D., Sette, A., Blackburn, J., Hsiao, M., Williamson, C., Riou, C., Goga, A., Garrett, N., Bekker, L., Gray, G., Ntusi, N., Moore, P., Burgers, W. (2021). Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner. https://doi.org/10.1101/2021.07.24.21261037

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Auteur(s)

Roanne Keeton Simone I. Richardson Thandeka Moyo-Gwete Tandile Hermanus Marius B. Tincho Ntombi Benede Nelia P. Manamela Richard Baguma Zanele Makhado Amkele Ngomti Thopisang Motlou Mathilda Mennen Lionel R. Chinhoyi Sango Skelem Hazel Maboreke Deelan Doolabh Arash Iranzadeh Ashley Otter Tim Brooks Mahdad Noursadeghi James Moon Alba Grifoni Daniela Weiskopf Alessandro Sette Jonathan M. Blackburn Marvin Hsiao Carolyn Williamson Catherine Riou Ameena Goga Nigel Garrett Linda‐Gail Bekker Glenda Gray Ntobeko Ntusi Penny L. Moore Wendy A. Burgers

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