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Population Pharmacokinetics with Monte Carlo Simulations of Gentamicin in a Population of Severely Ill Adult Patients from Sub-Saharan Africa

Article scientifique 2019 Anglais

Résumé

In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-intensive-care-unit (ICU) settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population treated with gentamicin ( n = 48) and developed a pharmacokinetic model using nonlinear mixed-effects modeling.

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Bos, J., Prins, J., Mistício, M., Nunguiane, G., Lang, C., Beirão, J., Mathôt, R., Hest, R. (2019). Population Pharmacokinetics with Monte Carlo Simulations of Gentamicin in a Population of Severely Ill Adult Patients from Sub-Saharan Africa. https://doi.org/10.1128/aac.02328-18

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Auteur(s)

Jeannet C. Bos Jan M. Prins Mabor C. Mistício Ginto Nunguiane Cláudia N Lang J. Beirão Ron A. A. Mathôt Reinier M. van Hest

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