11 publication(s) trouvée(s)
Article scientifique
Adiponectin levels during steady state and vaso-occlusive crisis in Nigerian children with sickle cell anaemia
Sickle cell anaemia (SCA) is a chronic inflammatory hemoglobinopathy marked by recurrent vaso-occlusive crises (VOC) and end-organ damage. Adiponectin, an …
Article scientifique
DARS expression in JAK2V617F-positive myeloproliferative neoplasms: immunohistochemical analysis and clinical associations
Aspartyl-tRNA synthetase (DARS) is implicated in several cancers, but its role in BCR::ABL-negative JAK2V617F-positive myeloproliferative neoplasms (MPNs) is unclear. This …
Article scientifique
Potential utility of PPARγ agonists in targeting chronic myeloid leukemia stem cells
Tyrosine kinase inhibitors (TKIs) have transformed the treatment of chronic myeloid leukemia (CML), yet persistent leukemia stem cells (LSCs) remain …
Article scientifique
The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia
β-thalassemia is an inherited blood disorder with long-term associated complications. The purpose of this study was to evaluate the clinical …
Article scientifique
Circulating miR-145-5p and miR-133a-3p in pediatric sickle cell disease: biomarker potential for vaso-occlusive crises and disease activity
MicroRNAs (miRNAs) involving miR-145-5p and miR-133a-3p are increasingly recognized for their roles in modulating inflammation, oxidative stress, and vascular integrity, …
Article scientifique
Updated Egyptian national guidelines for management of hemophilia A in children & adolescents
To improve patient advocacy in hemophilia, the World Federation of Hemophilia (WFH) recommends establishing a National Hemophilia Committee (NHC), developing …
Article scientifique
Early-life clinical and hematological profiles: a comparative study of children with and without sickle cell disease in the first three years of life
Sickle cell disease (SCD) has been associated with significant morbidity and mortality, particularly in early childhood. Understanding the hematological and …
Article scientifique
Outcome and response to different management regimens in pediatric patients with immune thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) is the most common acquired bleeding disorder in children and a frequent source of clinical concern. This …
Article scientifique
Zinc level and its impact on the phenotype of sickle cell disease
Zinc is an important antioxidant, and its deficiency contributes to oxidative damage in sickle cell disease (SCD). Emerging evidence supports …
Article scientifique
Use of hydroxyurea in French-speaking Sub-Saharan Africa
The hydroxyurea is a save, affordable and essential medicine for sickle cell disease (SCD), reducing painful crises and mortality. To …
Article scientifique
Targeting refractory diffuse large B cell lymphoma by CAR-WEE1 T-cells: In vitro evaluation
Refractory Diffuse Large B-cell Lymphoma (DLBCL) presents a major therapeutic challenge due to its resistance to standard treatments. Engineered T-cells, …