A new family of sulfamidophosphonates derivatives: Microwave-accelerated multicomponent synthesis, characterization and X-Ray Crystallographic Study.

Abstract In this present study we describe a simple, effective and greener one-pot microwave-assisted synthesis of novel α-sulfamidophosphonates4(a-n)that were rationally designed and synthesized following the principle of the superposition of bioactive substructures. This reaction was accomplished by the condensation of various aromatic aldehydes, sulfamide and diethyl phosphiteviaKabachnik-Fields reaction using ethanol as solvent under catalyst-free condition. The corresponding products were obtained with good yield, in short reaction time and no side product was observed. All the newly synthesized compounds were systematically characterized byIR,1H NMR,13C NMRand31P NMRanalysis and the structures of the compounds4band4cwere further analyzed by single crystal X-ray diffraction.