440 publication(s) trouvée(s)
Article scientifique
Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer
BACKGROUND: Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there …
Article scientifique
Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats
BACKGROUND: Colorectal cancer (CRC) is considered as the most common type of gastrointestinal cancers. Chemotherapy became limited due to the …
Article scientifique
Immunohistochemical Study of Ezrin Expression in Colorectal Carcinoma: A Comparative Study between Objective Method and Digital Quantitative Assessment
BACKGROUND: Colorectal cancer is one of the leading causes of cancer death in both developed and developing nations. It is …
Article scientifique
Estrogen and Progesterone Expression in Colorectal Carcinoma: A Clinicopathological Study
Sex steroids have been suggested to influence colorectal cancer (CRC) carcinogenesis. Also, exposure to exogenous hormones might contribute to its …
Article scientifique
XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population
Several major risk factors for hepatocellular carcinoma (HCC) have been identified, including chronic infection of hepatitis B virus (HBV) and …
Article scientifique
A Pilot Study of Extended Adjuvant Therapy with Metronomic Docetaxel for Patients with Operable Triple-Negative Breast Cancer
BACKGROUND: Triple-negative breast(TNBC) cancer is a molecular subtype of breast cancer with poor prognosis and did not get approved targeted …
Article scientifique
The Possible Role of Adipokines in HCV Associated Hepatocellular Carcinoma
BACKGROUND: Adipokines play an important role in the regulation of inflammation and tumor progression. AIM: Assessment of the possible role …
Article scientifique
Effect of Obesity on Neoadjuvant Systemic Therapy Outcomes in Patients with Early Breast Cancer: A Retrospective Institutional Study
BACKGROUND: Obesity and overweight are usually considered as poor prognostic factors in early breast cancer. Body mass index (BMI) is …
Article scientifique
Cisplatin Weekly Versus Every 3 Weeks Concurrently with Radiotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinomas: What Is the Best Dosing and Schedule?
PURPOSE: The aim of this prospective randomized study is to compare cisplatin at 2 dose levels given concurrently with intensity …
Article scientifique
Clinical Significance of CD200 and CD56 Expression in Patients with Acute Myeloid Leukemia
BACKGROUND: Acute myeloid leukemia (AML) escape from immunosurveillance by immunosuppression. CD200 and CD56 expression represented an independent prognostic factor in …
Article scientifique
Epithelial Cell Adhesion Molecule mRNA Can be a Potential Marker to Predict Metastasis in Hepatocellular Carcinoma Patients
OBJECTIVES: Epithelial cell adhesion molecule [EpCAM] is a surface marker of cancer stem cells that can maintain the capacity for …
Article scientifique
IDH Mutations in AML Patients; A higher Association with Intermediate Risk Cytogenetics
OBJECTIVE: IDH mutations diversely affect the prognosis of cyogenetically normal acute myeloid leukemia (CN-AML) adult patients. The aim of this …
Article scientifique
Analysis of Heterozygous BRCA1 5382ins Founder Mutation in a Cohort of Egyptian Breast Cancer Female Patients Using Pyrosequencing Technique
BACKGROUND: Up to half of the heritable mutations in breast cancer (BC) are attributed to BRCA1 and BRCA2 genes. The …
Article scientifique
Possible Prognostic Potential of RANKL and OPG in Metastatic Breast Cancer Egyptian Females
OBJECTIVES: Searching for sensitive, minimally invasive biomarkers that represent tumor-associated changes in the peripheral blood might enable the early diagnosis …
Article scientifique
Sociodemographic and Reproductive Risk Factors for Breast Cancer: A Case-Control Study in the Setif Province, Northern Algeria
BACKGROUND: The age-standardized rate of breast cancer (BC) increased nearly nine-fold in the last 30 years in Setif, Algeria. A …
Article scientifique
Assessment of Serum CoQ10 Levels and other Antioxidant Markers in Breast Cancer
BACKGROUND: The balance of the oxidative state in the body is fundamental for the maintenance of homeostasis. It has been …
Article scientifique
Tissue Profile of CDK4 and STAT3 as Possible Innovative Therapeutic Targets in Urinary Bladder Cancer
Bladder cancer represents a global health problem. It ranks ninth in worldwide cancer incidence. In Egypt, carcinoma of the bladder …
Article scientifique
Serum microRNA let-7a-1/let-7d/let-7f and miRNA 143/145 Gene Expression Profiles as Potential Biomarkers in HCV Induced Hepatocellular Carcinoma
BACKGROUND: Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Which make liver cirrhosis and hepatocellular carcinoma (HCC) …
Article scientifique
Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: Correlation between Androgen Receptor Expression and Pathological Response
BACKGROUND: There is growing evidence that the response to chemotherapy may be affected by Androgen Receptor (AR) expression suggesting that …
Article scientifique
The Micronuclei Scoring as a Biomarker for Early Detection of Genotoxic Effect of Cigarette Smoking
OBJECTIVE: The main aim of this study is to evaluate the micronuclei scoring as a biomarker for early detection and …