440 publication(s) trouvée(s)
Article scientifique
Clinical assessment of TGFB1 and HP Relative Gene Expression in the Peripheral Blood of Prostate Cancer Patients
OBJECTIVE: This study aimed to assess the relative gene expression level of transforming growth factor-β1 (TGFB1) and haptoglobin (HP) in …
Article scientifique
Effect of Radiotherapy on Activating the Pyroptotic Cell Death Pathway in Breast Cancer Patients: The Role of Serum GSDMD-CT, NLRP3 and IL-18
BACKGROUND: Breast cancer (BC) is the most common form of cancer among women and the second leading cause of cancer-related …
Article scientifique
Suppressor of Cytokine Signaling-3 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients in Egypt
BACKGROUND: Hepatocellular carcinoma (HCC) contributes significantly to cancer mortalities worldwide. The association between a specific single nucleotide polymorphism (SNP) located …
Article scientifique
Palliative and Supportive Care for Patients with End-Stage Hepatocellular Carcinoma: Perspectives of Egyptian Domestic Caregivers
OBJECTIVES: Palliative care is a holistic, patient-centered approach to improving the quality of life for those with terminal diseases and …
Article scientifique
Evaluation of HHLA2 and CD8 Immunohistochemical Expression in Colorectal Carcinoma and Their Prognostic Significance
BACKGROUND: Colorectal carcinoma (CRC) is the third most common malignancy worldwide. Human endogenous retrovirus H long terminal repeat-associating protein 2 …
Article scientifique
Clinicopathological Study of PD-1/PD-L1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) with Emphasis on Large B-Cell Richter Transformation
OBJECTIVE: In the era of immunotherapy, inhibition of the PD-1/PD-L1 immune checkpoint pathway has changed the therapeutic landscape for many …
Article scientifique
Frequency and Prognostic Impact of Aberrant Antigens Expression among Egyptian Adult Acute Leukemia
OBJECTIVE: Aberrant antigen expression was reported to be due to genetic and epigenetic dysregulation. This study aimed to address aberrant …
Article scientifique
Immunohistochemical Evaluation of Perlecan (Heparan Sulphate Proteoglycan 2) Expression in Invasive Female Breast Carcinoma
BACKGROUND: Breast cancer (BC) is the commonest type of female cancer worldwide and a leading cause of cancer-related deaths. Perlecan …
Article scientifique
Methylation Status of CDH1 Gene in Gastric Biopsy Specimens and Its Association with H. Pylori Infection
BACKGROUND: Helicobacter pylori (H. pylori) have been accepted as having an etiologic role in gastro-duodenal diseases as chronic gastritis, peptic …
Article scientifique
Prognostic Value of Immunohistochemical Expression of MTAP and AKIP1 in IDH1 Mutant Astrocytoma
BACKGROUND: Definite treatment for glioma is not exist, and with increased drug resistance, more effort should be paid to identify …
Article scientifique
Association of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Coding Variants with Hepatocellular Carcinoma Risk in the Moroccan Population: A Case-Control Study
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary malignancy. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) plays a …
Article scientifique
Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells
BACKGROUND: The miracle herb Nigella sativa (N. sativa) is a member of the Ranunculaceae family that possesses many properties, such …
Article scientifique
Class I HLA Allele Predicted Restricted Antigenic Coverages for Fap2 Protein of Fusobacterium Nucleatum Are Associated with Colorectal Cancer Incidence
OBJECTIVE: This study investigates the association between HLA-A and -B allele diversity, Fusobacterium nucleatum Fap2 protein-derived antigenic coverage, and colorectal …
Article scientifique
Genetic Polymorphism in FSCN1 rs3801004 C/G and CD44 rs353639 A/C, as Prognostic Factor in Egyptian Breast Cancer Patients
BACKGROUND: One of the main causes of cancer-related deaths is breast cancer. Fascin-1(FSCN1) is an actin-binding protein that is present …
Article scientifique
Impact of In- Service Training Program on Nurses’ Performance for Minimizing Chemotherapy Extravasation
OBJECTIVE: The objective of this study was to evaluate the impact of an in-service training program on nurses' performance in …
Article scientifique
Moesin and Ezrin as New Promising Markers for Early Detection of Endometrial Carcinoma: An Immunohistochemical Study
OBJECTIVE: the aim of this study is to evaluate immunohistochemically the expression of ezrin, and moesin, in endometrial lesion cases …
Article scientifique
Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma
OBJECTIVE: Osteosarcoma is considered the most common primary malignant tumor that develops from the primary osteoblasts. MiRNAs are small non-coding …
Article scientifique
Clinicopathologic Impact of NANOG, ZEB1, and EpCAM Biomarkers on Prognosis of Serous Ovarian Carcinoma
OBJECTIVES: Serous ovarian carcinoma (SOC) is a biologically heterogeneous with different genomic and molecular profiles, beside clinical response to the …
Article scientifique
Pediatric Nurses’ Perceived Competencies toward Palliative Care for Terminally Ill Children
INTRODUCTION: Paediatric palliative care involves the physical, psychological, and spiritual well-being of terminally ill children and their families. Competency in …
Article scientifique
Problems Affecting Accurate Dose Measurement in Small-Field for Linear Accelerator
BACKGROUND: The use of relatively narrow fields has become necessary with the advent of intricate and accurate radiation therapy delivery …