391 publication(s) trouvée(s)
Article scientifique
A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities
Abstract Impurity profiling of a pharmaceutical compound is now taking great attention during quality assessment of pharmaceuticals, as presence of …
Article scientifique
Fragment-based virtual screening discovers potential new Plasmodium PI4KIIIβ ligands
Type III beta phosphatidylinositol 4-kinase (PI4KIIIβ) is the only clinically validated drug target in Plasmodium kinases and therefore a critical …
Article scientifique
Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone
A new diazo derivative of a pyrrolidine-2,5-dione (8) fused at position-3,4 to a dibenzobarrelene backbone has been prepared by coupling …
Article scientifique
Synthesis, screening as potential antitumor of new poly heterocyclic compounds based on pyrimidine-2-thiones
BACKGROUND: Continuing our interest in preparing of new heterocyclic compounds and examining their various biological activities, this work was designed …
Article scientifique
Assessment of spatio-temporal variations of selected water quality parameters of Lake Ziway, Ethiopia using multivariate techniques
Abstract Excess agrochemicals input from agricultural activities and industrial effluent around Lake Ziway catchment can pose a serious threat on …
Article scientifique
Development and validation of liquid chromatography method for simultaneous determination of multiclass seven antibiotic residues in chicken tissues
Abstract Background Antibiotics are routinely used on poultry for therapy and prevention of diseases and to enhance animal growth. The …
Article scientifique
Synthesis, in silico molecular docking analysis, pharmacokinetic properties and evaluation of antibacterial and antioxidant activities of fluoroquinolines
Abstract Background Quinolines have demonstrated various biological activities such as antimalarial, antibacterial and anticancer. Hence, compounds with such scaffold have …
Article scientifique
Solvothermal synthesis of pure and Sn-doped Bi2S3 and the evaluation of their photocatalytic activity on the degradation of methylene blue
Abstract Background A large volume of dye molecules finds its way into the environment, accumulates in water bodies, and makes …
Article scientifique
Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study
Abstract Background Thiazole-based Schiff base compounds display significant pharmacological potential with an ability to modulate the activity of many enzymes …
Article scientifique
Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues
BACKGROUND: Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues were designed and synthesised as novel antimicrobial drugs through inhibition …
Article scientifique
Characterization and purification of Algerian natural bentonite for pharmaceutical and cosmetic applications
INTRODUCTION: Bentonitic clays from the Hammam Boughrara deposit in the Maghnia area (northwestern Algeria) were studied by mineralogical, chemical and …
Article scientifique
Statistical optimization of amorphous iron phosphate: inorganic sol–gel synthesis-sodium potential insertion
Abstract Iron phosphate, Fe2(HPO4)3*4H2O, is synthesized at ambient temperature, using the inorganic sol–gel method coupled to the microwave route. The …
Article scientifique
Chemical composition, energy and nutritional values, digestibility and functional properties of defatted flour, protein concentrates and isolates from Carbula marginella (Hemiptera: Pentatomidae) and Cirina butyrospermi (Lepidoptera: Saturniidae)
Edible insects constitute a potential source of alternative proteins as a food supplement. The present study aimed to investigate the …
Article scientifique
Evaluation of compost quality from municipal solid waste integrated with organic additive in Mizan–Aman town, Southwest Ethiopia
BACKGROUND: The present study evaluated the compost quality from municipal solid waste (MSW) and organic additives of coffee by-products and …
Article scientifique
A novel approach for the synthesis of nanostructured Ag3PO4 from phosphate rock: high catalytic and antibacterial activities
Abstract Background Silver orthophosphate (Ag3PO4) has received enormous attention over the past few years for its higher visible light photocatalytic …
Article scientifique
Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5
BACKGROUND: Cucumis prophetarum is traditionally used to treat liver and lung disorders, heart failure, diarrhea, gonorrhea, skin infections, intestinal problems …
Article scientifique
Experimental and computational studies of an antiplasmodial derivative of allantoin; antimycobacterial essential oil from Cordia batesii WERNHAM (Boraginaceae)
Abstract Background Chemical and pharmacological investigations were performed on the stems of Cordia batesii (Boraginaeae); chemical studies included quantum calculations …
Article scientifique
Dioxin and dibenzofuran like molecular analogues from the pyrolysis of biomass materials—the emerging challenge in bio-oil production
INTRODUCTION: The aggressive search for renewable energy resources and essential pyrosynthetic compounds has marked an exponential rise in the thermal …
Article scientifique
Salting-out induced liquid–liquid microextraction for alogliptin benzoate determination in human plasma by HPLC/UV
Salting-out induced liquid-liquid microextraction method has been developed for plasma sample treatment before determination of alogliptin by high performance liquid …
Article scientifique
Spectral, thermal, antimicrobial studies for silver(I) complexes of pyrazolone derivatives
Abstract Background Synthesize new complexes of Ag(I) to enhance efficacy or stability and also, pharmacological activities on the operation of …