269 publication(s) trouvée(s)
Article scientifique
Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis
The high prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide necessitates the attention and intervention of modern medical treatment options. …
Article scientifique
Antimicrobial activity of Salvia spinosa against Enterococcus faecalis causing endodontic infections: an in-vitro, ex-vivo, and in-silico study
Abstract Background Enterococcus faecalis (E. faecalis) often persists in root canal systems and it is rather unsusceptible to many root …
Article scientifique
Rosmarinus Officinalis L. essential oil: in Silico molecular docking and in vivo nematocidal activity on intestinal and muscular trichinellosis
BACKGROUND: Despite its deleterious effects, modest activity in muscular larval stages and burgeoning resistance, the control of trichinellosis relies primarily …
Article scientifique
Nanoparticles from grape seed extract inhibit inflammatory cytokines and ameliorate CCl4-induced hepatotoxicity
Abstract Background Xenobiotic-induced liver injury is a clinically reverent condition which may influence the development of steatohepatitis via affecting numerous …
Article scientifique
Melatonin as a potential adjuvant to mitigate depakine‑induced testicular damage in rats through its biological features
BACKGROUND: Depakine (valproic acid) is an antiepileptic medication that is commonly used as a first-line treatment for a variety of …
Article scientifique
The role of traditional medicine in providing palliative care and improving the quality of life: a survey on patients’ knowledge and utilization in Kumasi metropolis, Ghana
BACKGROUND: According to the World Health Organization (WHO) the utilization of traditional medicine items exceeds that of conventional medications by …
Article scientifique
The first record of biological activities and chemical constituents of different extracts and semi-purified fractions of Bidens aurea (Aiton) Sherff (Asteraceae)
Abstract Bidens aurea is a flowering plant known for its yellow or white flowers rich with various bioactive chemical compounds …
Article scientifique
Mitigation of radiation mediated testicular dysfunction by α-tocopheryl succinate: PPAR-γ related pathway
BACKGROUND: Radiation exposure of sensitive organs during radiotherapy merits extraordinary consideration, particularly when the concern is about fertility. Although alpha-tocopheryl …
Article scientifique
Investigating the potential scabicidal activities of three essential oils: gaining mechanistic insights through in vitro contact bioassay and molecular docking
BACKGROUND: Scabies, sarcoptic itch, is a highly contagious and pruritic skin inflammation. Given their ecological benefits and previous therapeutic properties, …
Article scientifique
Chemical profiling and anticancer activity of Alnus incana dichloromethane fraction on HeLa cells via cell cycle arrest and apoptosis
BACKGROUND: Cervical cancer remains a global health challenge with persistently high incidence and mortality rates despite advancements in conventional treatments. …
Article scientifique
Comparative chemical and antimicrobial evaluation of the essential oils from Callistemon and podocarpus species supported by in-silico molecular simulations against bacterial LacY protease
BACKGROUND: Myrtaceae and Podocarpaceae botanical families include several aromatic species that have been proven to have diverse pharmacological potential, especially …
Article scientifique
Quorum sensing inhibition by South African medicinal plants species: an in vitro and an untargeted metabolomics study
Abstract Background The emergence of antimicrobial resistance (AMR) is imperiling global health, hence, the need to remedy this challenge by …
Article scientifique
Pharmacological assessment of the extract and a novel compound of Bacillus velezensis DM derived from the rhizosphere of Datura metel L. with microbial molecular screening
Abstract Background Rhizosphere bacteria were considered a prospective reservoir of bioactive compounds with significant pharmacological efficacy. Methods From the rhizosphere …
Article scientifique
Computational development of mushroom-6-glucan/paclitaxel as a synergistic complementary medicine for breast cancer therapy
BACKGROUND: Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to …
Article scientifique
Exploring the therapeutic potential of marjoram (Origanum majorana L.) in polycystic ovary syndrome: insights from serum metabolomics, network pharmacology and experimental validation
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder with significant metabolic and hormonal dysregulation. Marjoram (Origanum majorana L.), …
Article scientifique
Phytochemical and antibacterial properties of calyces Hibiscus sabdariffa L.: an in vitro and in silico multitarget-mediated antibacterial study
BACKGROUND: Multidrug-resistant (MDR) bacteria pose a significant threat to human health worldwide by increasing the harmful impact of traditional synthetic …
Article scientifique
Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn.
Abstract Duranta erecta Linn. belongs to the Verbenaceae family and is primarily found in subtropical, tropical, and temperate climates. The …
Article scientifique
Exploring the contribution of integrated healthcare practices to malaria control in Ghana: perspectives of medical herbalists
BACKGROUND: The integration of herbal and orthodox medicines has gained momentum in global health, ensuring improved management of infectious diseases …
Article scientifique
Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron
BACKGROUND: Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential …
Article scientifique
Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and biological verification
BACKGROUND: Oral squamous cell carcinoma (OSCC) ranks as the sixth most common malignancy globally. Cisplatin is the standard chemotherapy for …