269 publication(s) trouvée(s)
Article scientifique
The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats
BACKGROUND: Vortioxetine (VORTX) is a potent and selective type of selective serotonin reuptake inhibitor (SSRI) that is mainly prescribed for …
Article scientifique
Evidence on the inhibitory effect of Brassica plants against Acinetobacter baumannii lipases: phytochemical analysis, in vitro, and molecular docking studies
BACKGROUND: Infections caused by Acinetobacter baumannii are becoming a rising public health problem due to its high degree of acquired …
Article scientifique
LC-MS/MS profiling of Tipuana tipu flower, HPLC-DAD quantification of its bioactive components, and interrelationships with antioxidant, and anti-inflammatory activity: in vitro and in silico approaches
Abstract Background Fabaceae plays a crucial role in African traditional medicine as a source of large number of important folk …
Article scientifique
Phytochemical characterization, antimicrobial and antioxidant activities of Terminalia catappa methanol and aqueous extracts
BACKGROUND: A study carried out by World Health Organization revealed that around 80% of individuals globally depends on herbal forms …
Article scientifique
Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential
INTRODUCTION: Silybum marianum commonly known as milk thistle is one of the most imperative medicinal plants due to its remarkable …
Article scientifique
Will Nigella sativa oil protect parotid glands of rats against cranium gamma irradiation? Histological and immunohistochemical evaluation
BACKGROUND: Radiation plays an essential role in treating malignancies. Radiation exposure of salivary glands often results in permanent loss of …
Article scientifique
Insight into antioxidant-like activity and computational exploration of identified bioactive compounds in Talinum triangulare (Jacq.) aqueous extract as potential cholinesterase inhibitors
BACKGROUND: Recent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders such as Alzheimer's …
Article scientifique
In vitro antibacterial activity of fruit pulp extracts of Tamarindus indica against Staphylococcus aureus and Klebsiella pneumoniae
BACKGROUND: Infectious diseases are increasingly recognized as public health concern worldwide as the rising incidence in multidrug resistance bacteria. This …
Article scientifique
Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts
Abstract Background The Convolvulus genus is distributed all over the world and has a long history in traditional medicine. As …
Article scientifique
Phytochemical analysis and evaluation of its antioxidant, antimicrobial, and cytotoxic activities for different extracts of Casuarina equisetifolia
BACKGROUND: Casuarina equisetifolia belongs to the Casuarina species with the most extensive natural distribution, which contain various phytochemicals with potential …
Article scientifique
Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum
Abstract Background Hepatocyte death and a systemic inflammatory response are the outcome of a complex chain of events mediated by …
Article scientifique
The neuroprotective potential of curcumin on T. Spiralis infected mice
BACKGROUND: Trichinella spiralis can affect the brain by inducing inflammatory and vascular changes. Drug management with the antiparasitic drug albendazole …
Article scientifique
Chemical and biological characterization of Melaleuca subulata (Cheel) Craven leaves’ volatile constituents supported by chemometric analysis and molecular docking
BACKGROUND: The genus Melaleuca (Myrtaceae) comprises dozens of essential oil (EO)-rich species that are appreciated worldwide for their various medicinal …
Article scientifique
The study of wound healing activity of Thespesia populnea L. bark, an approach for accelerating healing through nanoparticles and isolation of main active constituents
The present study provides an evaluation for the wound healing activity of the ethanolic extract of Thespesia populnea L. bark …
Article scientifique
Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats
BACKGROUND: Melissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely …
Article scientifique
Development of propolis, hyaluronic acid, and vitamin K nano-emulsion for the treatment of second-degree burns in albino rats
Abstract Burns are the fourth most common type of injury worldwide. Many patients also suffer numerous infections and complications that …
Article scientifique
Phytochemical screening and antimicrobial activity of Polygala sadebeckiana Gürke extracts on bacterial isolates from Wound samples of patients with “Shimetere”
BACKGROUND: Modern medicine is not the choice of patients with "shimetere" in the Gurage community owing to their perception of …
Article scientifique
Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins
BACKGROUND: Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to …
Article scientifique
Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations
BACKGROUND: Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of the stomach and …
Article scientifique
In vitro anti-HIV, cytotoxicity and nutritional analysis of Trianthema portulacastrum L. (Aizoaceae)
Abstract The development of antiretroviral therapy has brought a tremendous relief to the world as it minimizes mortality, reduces HIV …