49 publication(s) trouvée(s)
Article scientifique
Causal estimation of time-varying treatments in observational studies: a scoping review of methods, applications, and missing data practices
BACKGROUND: Estimating causal effects of time-varying treatments or exposures in observational studies is challenging due to time-dependent confounding and missing …
Article scientifique
A systematic review of mediation analysis frameworks in studies examining the determinants of cardiometabolic outcomes in people living with HIV
INTRODUCTION: Mediation analysis provides a more flexible mechanistic view of the causal relationship between HIV-related factors and cardiometabolic diseases. However, …
Article scientifique
Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis
BACKGROUND: Systematic review with meta-analysis integrates findings from multiple studies, offering robust conclusions on treatment effects and guiding evidence-based medicine. …
Article scientifique
Socio-environmental predictors of diabetes incidence disparities in Tanzania mainland: a comparison of regression models for count data
BACKGROUND: Diabetes is one of the top four non-communicable diseases that cause death and illness to many people around the …
Article scientifique
Flexible Bayesian semiparametric mixed-effects model for skewed longitudinal data
BACKGROUND: In clinical trials and epidemiological research, mixed-effects models are commonly used to examine population-level and subject-specific trajectories of biomarkers …
Article scientifique
Exploring trial publication and research waste in COVID-19 randomised trials of hydroxychloroquine, corticosteroids, and vitamin D: a meta-epidemiological cohort study
BACKGROUND: The global research response to the COVID-19 pandemic was impressive, but also led to an infodemic and considerable research …
Article scientifique
Promoting data harmonization to evaluate vaccine hesitancy in LMICs: approach and applications
BACKGROUND: Factors influencing the health of populations are subjects of interdisciplinary study. However, datasets relevant to public health often lack …
Article scientifique
Advancing guideline quality through country-wide and regional quality assessment of CPGs using AGREE: a scoping review
BACKGROUND AND OBJECTIVE: Clinical practice guidelines (CPGs) are evaluated for quality with the Appraisal of Guidelines for Research and Evaluation …
Article scientifique
The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial
INTRODUCTION: Symptoms reported following the administration of investigational drugs play an important role in decisions for registration and treatment guidelines. …
Article scientifique
Data quality in an HIV vaccine efficacy clinical trial in South Africa: through natural disasters and with discipline
BACKGROUND: To produce quality data that informs valid clinical trial results and withstands regulatory inspection, trial sites should adhere to …
Article scientifique
Development and validation of a screening tool for SPondyloArthritis Screening in Sub-Saharan Africa: SpASSS questionnaire
OBJECTIVE: To develop and validate a screening tool to identify patients with a high likelihood for Spondyloarthritis (SpA) in the …
Article scientifique
Using joint models to study the association between CD4 count and the risk of death in TB/HIV data
BACKGROUND: The association structure linking the longitudinal and survival sub-models is of fundamental importance in the joint modeling framework and …
Article scientifique
Measuring and exploring mental health determinants: a closer look at co-residents’ effect using a multilevel structural equations model
OBJECTIVE: Previous research has demonstrated that individual risk of mental illness is associated with individual, co-resident, and household risk factors. …
Article scientifique
Developing an Unstructured Supplementary Service Data-based mobile phone app to provide adolescents with sexual reproductive health information: a human-centered design approach
BACKGROUND: Adolescent pregnancies and sexually-transmitted infections continue to impact 15 - 19-year-olds across the globe. The lack of sexual reproductive …
Article scientifique
Identifying Potential Factors Associated with High HIV viral load in KwaZulu-Natal, South Africa using Multiple Correspondence Analysis and Random Forest Analysis
BACKGROUND: Sustainable Human Immunodeficiency Virus (HIV) virological suppression is crucial to achieving the Joint United Nations Programme of HIV/AIDS (UNAIDS) …
Article scientifique
Estimation of invasive Group B Streptococcus disease risk in young infants from case-control serological studies
BACKGROUND: Group B Streptococcus (GBS) infections are a major cause of invasive disease (IGbsD) in young infants and cause miscarriage …
Article scientifique
Developing a tool to assess the skills to perform a health technology assessment
BACKGROUND: Health technology assessment (HTA) brings together evidence from various disciplines while using explicit methods to assess the value of …
Article scientifique
Comparison of statistical methods for the analysis of recurrent adverse events in the presence of non-proportional hazards and unobserved heterogeneity: a simulation study
BACKGROUND: In preventive drug trials such as intermittent preventive treatment for malaria prevention during pregnancy (IPTp), where there is repeated …
Article scientifique
Improving retention of community-recruited participants in HIV prevention research through Saturday household visits; findings from the HPTN 071 (PopART) study in South Africa
BACKGROUND: Identifying successful strategies to improve participant retention in longitudinal studies remains a challenge. In this study we evaluated whether …
Article scientifique
A simulation study for evaluating the performance of clustering measures in multilevel logistic regression
BACKGROUND: Multilevel logistic regression models are widely used in health sciences research to account for clustering in multilevel data when …
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