91 publication(s) trouvée(s)
Article scientifique
Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover
BACKGROUND: Fluoxetine is present in breast milk, yet it is unclear to what extent it, or its active metabolite, norfluoxetine, …
Article scientifique
Differential impact of pegfilgrastim, a recombinant human granulocyte colony stimulating factor, on the neutrophil count of male and female deer mice (Peromyscus maniculatus bairdii)
BACKGROUND: An increasing body of research implicates inflammatory processes, including alterations in the neutrophil-lymphocyte ratio (NLR), in the pathophysiology of …
Article scientifique
Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity
Abstract This study reports a novel, eco-friendly; fast and cost-effective microwave method for synthesizing carboxymethylated graphene oxide (CMGO) from sugarcane …
Article scientifique
Pharmacokinetics of piperaquine and its association with intermittent malaria preventive therapy outcomes during pregnancy
BACKGROUND: Dihydroartemisinin-piperaquine (DHP) recently showed superior effectiveness over sulfadoxine-pyrimethamine for malaria intermittent preventive treatment in pregnancy (IPTp). We investigated day …
Article scientifique
Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin
BACKGROUND: Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some …
Article scientifique
Prevalence and factors associated with potential drug-drug interactions in prescriptions presented at private pharmacies in Mbarara city, southwestern Uganda
BACKGROUND: Drug-drug interactions (DDIs) influence the effectiveness of medication and thus determine the treatment outcomes of diseases managed with pharmacotherapy. …
Article scientifique
Levocetrizine attenuates cyclophosphamide-induced lung injury through inhibition of TNF-α, IL-1β, TGF-β and MMP-9
Cyclophosphamide (CP) is an antineoplastic drug commonly used worldwide. Despite its spread, it causes fatal organ toxicity. Lung toxicity is …
Article scientifique
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
BACKGROUND: Atherosclerosis is a form of cardiovascular disease that affects the endothelium of the blood vessel. Series of events are …
Avis de rétractation
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
Article scientifique
Butyrate alleviates renal inflammation and fibrosis in a rat model of polycystic ovarian syndrome by suppression of SDF-1
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a multifactorial condition with metabolic-related complications, such as diabetic nephropathy and chronic renal disorder, …
Article scientifique
Berberine-loaded albumin nanoparticles reverse aflatoxin B1-induced liver hyperplasia
Hepatocellular carcinoma (HCC) can be produced from aflatoxin B1 (AFB1) administration. Although berberine (BER) acts as an anticancer agent and …
Article scientifique
In vitro comparative quality evaluation of different brands of carbamazepine tablets commercially available in Dessie town, Northeast Ethiopia
BACKGROUND: Good-quality drugs that fulfill the regulatory parameters and are produced per the current good manufacturing practice (cGMP) standards are …
Article scientifique
In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia
Abstract Background The plants Aloe weloensis, Lepidium sativum, and Lobelia gibberoa have been used in Ethiopian folklore medicine to treat …
Article scientifique
β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder. The naturally occurring phytosterol; β-sitosterol has antiobesogenic and …
Article scientifique
Effect of renin angiotensin blockers on angiotensin converting enzyme 2 level in cardiovascular patients
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) is hypothesized to be in the center of COVID pathophysiology as the angiotensin converting enzyme 2 …
Article scientifique
The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats
BACKGROUND: Anabolic steroids (AS) are commonly abused by body builders and athletes aiming to increase their strength and muscle mass …
Article scientifique
Controlled release of silica-coated insulin-loaded chitosan nanoparticles as a promising oral administration system
BACKGROUND: Oral insulin administration has recently become one of the most exciting research subjects. Different approaches have been carried out …
Article scientifique
Profile and outcomes of acute poisoning in the toxicology treatment and control center at Tanta University Hospital, Egypt
BACKGROUND: Poisoning is a major health problem especially in developing countries and leads to high morbidity and mortality. AIM: To …
Article scientifique
Sea urchin (Diadema savignyi) extract as a novel protective agent against cisplatin induced neurotoxicity in rats
Abstract Neurotoxicity is a severe side effect of platinum compounds used for cancer chemotherapy such as Cisplatin. This neurotoxicity leads …
Article scientifique
Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212–2 administration in mice
WIN55, 212-2 mesylate is a synthetic cannabinoid (SC) agonist of CB1 and CB2 receptors with much higher affinity to CB1 …