220 publication(s) trouvée(s)
Article scientifique
Tumor lysis syndrome in children with hematological malignancies: a nephrology perspective in resource-limited settings
Background: Tumor lysis syndrome (TLS) is a major metabolic emergency in pediatric oncology and a leading cause of acute kidney …
Article scientifique
Women with suspected diagnosis of ovarian cancer in Ghana: how much do we know about them?
Background: Addressing disparities in ovarian cancer care between sub-Saharan Africa and other regions begins with the fundamental question, "Who gets …
Article scientifique
PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific molecular heterogeneity in the Nigerian breast cancer landscape
Introduction: Breast cancer (BC) is a molecularly heterogeneous disease, and treatment outcomes are strongly shaped by subtype-specific signalling dependencies. However, …
Éditorial
Editorial: Innovations in supportive care in global pediatric oncology
Over 90% of children diagnosed with cancer live in low-and middle-income countries (LMICs) where the cure rate is under 30% …
Article scientifique
Internalized stigma among pediatric patients with osteosarcoma and retinoblastoma in Guatemala, Jordan, and Zimbabwe
Introduction Internalized stigma adversely impacts childhood cancer survivors, limiting their ability to reintegrate with their communities and maintain social networks. …
Article scientifique
Pilot study: predicting the interplay between FOXO1 and its downstream long non-coding RNAs in HCC
Introduction Forkhead Box O-1 ( FOXO1 ) is one of the key regulatory transcription factors capable of regulating many critical …
Article scientifique
Myth or reality: the oxygen effect in rectal cancer radiotherapy
Background: The oxygen microenvironment plays a crucial role in tumor radio-sensitivity, influencing the effectiveness of radiotherapy. The oxygen effect, which …
Article scientifique
Prospective multicenter study evaluating safety, tolerability and metabolism of niraparib as maintenance for ovarian cancer in women of African ancestry
Large-scale clinical studies investigating the safety and efficacy of novel therapeutics in ovarian cancer rarely include Black women or women …
Article scientifique
Perioperative FLOT chemotherapy versus neoadjuvant chemoradiotherapy (CROSS protocol) in locally advanced adenocarcinoma of the lower oesophagus and oesophagogastric junction (Siewert types I–II): systematic review and narrative synthesis (SWiM)
Background Adenocarcinoma of the lower oesophagus and oesophagogastric junction (OGJ) is a malignancy of rising incidence in Western countries. Two …
Article scientifique
The high price of innovation: addressing financial toxicity and healthcare inequity in gynecological malignancies
Over the past decade, gynecological oncology has transitioned into an era of precision medicine, immune-targeted therapies, minimally invasive robotic surgery, …
Article scientifique
A combined tumor burden–based nomogram for synchronous esophageal and gastric cancers: development and external validation
Background: Synchronous dual-primary esophageal and gastric cancers (SEGC) are rare upper gastrointestinal malignancies presenting substantial challenges for prognostic assessment and …
Article scientifique
Brain metastasis secondary to primary vaginal clear cell adenocarcinoma not associated with diethylstilbestrol: a case report and a review of the literature
Background: exposure to diethylstilbestrol (DES). Patients with non-DES-related PCCAV are even scarcer and usually have a worse prognosis. PCCAV has …
Article scientifique
Integrating artificial intelligence across the cancer drug discovery pipeline using a design-test-refine workflow
Artificial intelligence-driven drug design (AIDD) is increasingly transforming cancer drug discovery, but its applications are often considered as individual computational …
Article scientifique
Oral selective estrogen receptor degraders in ER+/HER2− breast cancer: a systematic review with pooled analysis of metastatic randomized trials and narrative synthesis of adjuvant evidence
Background Oral selective estrogen receptor degraders (SERDs) have become a key therapeutic option for hormone receptor-positive, HER2−negative advanced breast cancer. …
Article scientifique
State of high-grade glioma care in Africa: insights from a scoping review of the available published literature
Background: High-grade gliomas (HGGs), WHO grade 3-4 diffuse gliomas, are aggressive primary brain tumors. Evidence on their management and outcomes …
Article scientifique
AI-enabled D-dimeromics in precision breast oncology: a transformative framework for the identification, stratification, and prognostication of ultra-high-risk disease phenotypes
Breast cancer is a highly diverse ailment marked by various molecular subtypes, differing clinical paths, and unique treatment reactions. Notwithstanding …
Article scientifique
Addressing the cancer burden in LMICs: the potential of modulated electro-hyperthermia
Cancer in low- and middle-income countries (LMICs) is associated with late-stage diagnoses and poor survival, compounded by limited access to …
Article scientifique
Surgical management and outcome of medulloblastoma patients at Addis Ababa between 2010 and 2018
Background: Medulloblastoma is the most common malignant central nervous system tumor in pediatric patients and is relatively rare in adults. …
Article scientifique
The implication of aberrant NRF2 activation in management of female cancers
The overactivation of NRF2 (Nuclear factor erythroid 2-related factor 2) in female malignancies is an emerging field of study with …
Article scientifique
Clinical outcome of 115 patients with synchronous bilateral Wilms’ tumor: largest cohort of single-center experience
Introduction: Bilateral Wilms' tumor (BWT) represents 5 - 8% of patients with Wilms' tumor (WT). Despite the improvement of WT …