486 publication(s) trouvée(s)
Article scientifique
Ocimum basilicum Essential Oil Modulates Hematotoxicity, Oxidative Stress, DNA Damage, and Cell Cycle Arrest Induced by β-cyfluthrin in Rat Liver
Pesticides are used in large quantities infrequently, resulting in environmental damage and health issues. The goal of the current study …
Article scientifique
Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties
Medicinal plants have been used since ancient times for human healthcare as drugs, spices, and food additives. The progress in …
Article scientifique
AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma
HIF-1α is a key factor promoting the development of hepatocellular carcinoma (HCC). As well, AKT-AMPKα-mTOR signaling is a promising target …
Article scientifique
Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death
Within the last decade, several peptides have been identified according to their ability to inhibit the growth of microbial pathogens. …
Article scientifique
Treating Rare Diseases in Africa: The Drugs Exist but the Need Is Unmet
Rare diseases (RD) pose serious challenges in terms of both diagnosis and treatment. Legislation was passed in the US (1983) …
Article scientifique
Culinary Spices in Food and Medicine: An Overview of Syzygium aromaticum (L.) Merr. and L. M. Perry [Myrtaceae]
Spices-dried aromatic parts of plants (leaves, seeds, bark, roots, rhizomes, buds, etc) used to enhance flavour, taste and colour (sensory …
Article scientifique
Contextualising the Perceptions of Pharmacists Practicing Clinical Pharmacy in South Africa—Do We Practice what We Preach?
The National Department of Health published their Quality Standards for Healthcare Establishments in South Africa and introduced the National Health …
Article scientifique
RETRACTED: Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy in Rats
Sciatic nerve injury is often associated with neuropathic pain and neuroinflammation in the central and peripheral nervous systems. In our …
Article scientifique
Potential Benefits of Antiviral African Medicinal Plants in the Management of Viral Infections: Systematic Review
Background: Viruses cause various human diseases, some of which become pandemic outbreaks. This study synthesized evidence on antiviral medicinal plants …
Article scientifique
Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids
Cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Over the last few …
Article scientifique
Syzygium aqueum (Burm.f.) Alston Prevents Streptozotocin-Induced Pancreatic Beta Cells Damage via the TLR-4 Signaling Pathway
Although several treatments are available for the treatment of type 2 diabetes mellitus, adverse effects and cost burden impose the …
Article scientifique
Phytomedicine in Disease Management: In-Silico Analysis of the Binding Affinity of Artesunate and Azadirachtin for Malaria Treatment
In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit …
Article scientifique
HIV Protease Inhibitors and Insulin Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Protease inhibitors (PIs) are believed to affect insulin sensitivity. We aimed to analyze the effect of PIs on insulin …
Article scientifique
Medicinal Plants Used by Traditional Healers in Algeria: A Multiregional Ethnobotanical Study
Traditional medicine is the cornerstone that boosts scientific research to explore new therapeutic approaches. The study aimed to assess the …
Article scientifique
Ginger from Farmyard to Town: Nutritional and Pharmacological Applications
Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating …
Article scientifique
Carbon Monoxide in Pancreatic Islet Transplantation: A New Therapeutic Alternative to Patients With Severe Type 1 Diabetes Mellitus
Pancreatic islet transplantation is a minimally invasive procedure to replace β-cells in a subset of patients with autoimmune type 1 …
Article scientifique
Antidiabetic Medicinal Plants Used in Democratic Republic of Congo: A Critical Review of Ethnopharmacology and Bioactivity Data
Several studies have been conducted and published on medicinal plants used to manage Diabetes Mellitus worldwide. It is of great …
Article scientifique
Investigation of Angiogenesis and Wound Healing Potential Mechanisms of Zinc Oxide Nanorods
The angiogenesis process is an essential issue in tissue engineering. Zinc oxide nanorods are biocompatible metals capable of generating reactive …
Article scientifique
Targeting of Protein’s Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L
The possible evolutionary trend of COVID-19 in South Africa was investigated by comparing the genome of SARS-CoV-2 isolated from a …
Article scientifique
Opioids and Gabapentinoids Utilisation and Their Related-Mortality Trends in the United Kingdom Primary Care Setting, 2010–2019: A Cross-National, Population-Based Comparison Study
Background: There is growing concern over the increasing utilisation trends of opioids and gabapentinoids across but there is lack of …