9 publication(s) trouvée(s)
Article scientifique
CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infection
Plasmodium falciparum (Pf) induces the clonal expansion of antigen-specific type 1 regulatory T (Tr1) cells capable of long-term memory. Tr1 …
Article scientifique
Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort
BACKGROUNDSusceptibility to HIV-1 infection varies between individuals, but the biological determinants of acquisition risk remain poorly defined.METHODSWe conducted a case-control …
Article scientifique
Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses
Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying genetic and cellular mechanisms …
Article scientifique
A whole-body imaging technique for tumor-specific diagnostics and screening of B7H3-targeted therapies
BACKGROUNDB7H3, also known as CD276, is notably overexpressed in various malignant tumor cells in humans, with extremely high expression rates. …
Article scientifique
HOPE springs eternal: lack of HIV superinfection in HIV Organ Policy Equity Act kidney transplants
Kidney transplantation from donors with HIV to recipients with HIV (HIV D+/R+) is an emerging practice that has shown substantial …
Article scientifique
A randomized first-in-human phase I trial of differentially adjuvanted Pfs48/45 malaria vaccines in Burkinabé adults
BACKGROUNDMalaria transmission-blocking vaccines aim to interrupt the transmission of malaria from one person to another.METHODSThe candidates R0.6C and ProC6C share …
Article scientifique
Prevalence and functional profile of SARS-CoV-2 T cells in asymptomatic Kenyan adults
BackgroundSARS-CoV-2 infection in Africa has been characterized by a less severe disease profile than what has been observed elsewhere, but …
Article scientifique
O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission
Major depressive disorder is a common and devastating psychiatric disease, and the prevalence and burden are substantially increasing worldwide. Multiple …
Article scientifique
Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity
Determinants of the acquisition and maintenance of maternal microchimerism (MMc) during infancy and the impact of MMc on infant immune …