35 publication(s) trouvée(s)
Article scientifique
Predicting mortality in critically ill patients: a machine learning approach to electrolyte imbalances and clinical risk factors
BACKGROUND: Critically ill patients in intensive care units (ICUs) exhibit high mortality due to complex interactions among metabolic instability, organ …
Article scientifique
Exploiting artificial intelligence in precision oncology: an updated comprehensive review
Precision oncology considers the genetic makeup of both the tumor and the cancer patient, medical history, clinical metadata, lifestyle and …
Article scientifique
TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity
BACKGROUND: Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to …
Article scientifique
Comparative analysis of statistical and deep learning-based multi-omics integration for breast cancer subtype classification
BACKGROUND: Breast cancer (BC) is a critical cause of cancer-related death globally. The heterogeneity of BC subtypes poses challenges in …
Article scientifique
Viruses and neurodegeneration: a growing concern
Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis …
Article scientifique
Network medicines™
Article scientifique
Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction
BACKGROUND: A major obstacle to the development of personalized therapies for gastric cancer (GC) is the prevalent heterogeneity at the …
Article scientifique
Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management
Liver fibrosis is a liver disease in which there is an excessive buildup of extracellular matrix proteins, including collagen. By …
Article scientifique
Effect of Omega-3 fatty acids supplementation on serum level of C-reactive protein in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
BACKGROUND: Omega-3 may alleviate the severity of coronavirus disease 2019 (COVID-19) by reducing the C-reactive protein (CRP) level, a marker …
Article scientifique
IDO/kynurenine pathway in cancer: possible therapeutic approaches
Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes …
Article scientifique
Exosomes contribution in COVID-19 patients’ treatment
Adipose cell-free derivatives have been recently gaining attention as potential therapeutic agents for various human diseases. In this context, mesenchymal …
Article scientifique
A versatile web app for identifying the drivers of COVID-19 epidemics
BACKGROUND: No versatile web app exists that allows epidemiologists and managers around the world to comprehensively analyze the impacts of …
Article scientifique
Novel and recurrent BRCA1/BRCA2 germline mutations in patients with breast/ovarian cancer: a series from the south of Tunisia
BACKGROUND: The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in Tunisia especially in young women and …
Article scientifique
Influence of COVID-19 on lifestyle behaviors in the Middle East and North Africa Region: a survey of 5896 individuals
BACKGROUND: Coronavirus disease (COVID-19) pandemic has affected health and lifestyle behaviors of people globally. This project aims to identify the …
Article scientifique
Translational research in Uganda: linking basic science to bedside medicine in a resource limited setting
BACKGROUND: Translational research is a process of applying knowledge from basic biology and clinical trials to techniques and tools that …
Article scientifique
Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size
BACKGROUND: Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and …
Erratum
Correction to: Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy
Following publication of the original article [1], the authors reported errors in Figures 2, 3 and Figure 3 'continued'.
Article scientifique
Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?
BACKGROUND: Meningitis can be caused by several viruses and bacteria. Identifying the causative pathogen as quickly as possible is crucial …
Article scientifique
Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
BACKGROUND: Triple negative breast cancer (TNBC) has been classified as a disease subgroup defined by the lack of expression of …
Article scientifique
Identification of potential miRNA–mRNA regulatory network contributing to pathogenesis of HBV-related HCC
BACKGROUND: Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that …
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