1722 publication(s) trouvée(s)
Article scientifique
Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border
BACKGROUND: A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The …
Article scientifique
Efficacies of DHA–PPQ and AS/SP in patients with uncomplicated Plasmodium falciparum malaria in an area of an unstable seasonal transmission in Sudan
BACKGROUND: Artemisinin-based combination therapy (ACT), together with other control measures, have reduced the burden of falciparum malaria in sub-Saharan countries, …
Article scientifique
The malaria testing and treatment landscape in mainland Tanzania, 2016
BACKGROUND: Understanding the key characteristics of malaria testing and treatment is essential to the control of a disease that continues …
Article scientifique
Ivermectin to reduce malaria transmission II. Considerations regarding clinical development pathway
The development of ivermectin as a complementary vector control tool will require good quality evidence. This paper reviews the different …
Article scientifique
Spatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea
BACKGROUND: The transmission of malaria is intense in the majority of the countries of sub-Saharan Africa, particularly in those that …
Article scientifique
Increase in the prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso
BACKGROUND: Pregnant women are a high-risk group for Plasmodium falciparum infections, which may result in maternal anaemia and low birth …
Article scientifique
The malaria testing and treatment landscape in Benin
BACKGROUND: Since 2004, artemisinin-based combination therapy (ACT) has been the first-line treatment for uncomplicated malaria in Benin. In 2016, a …
Article scientifique
Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s.
BACKGROUND: Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor …
Article scientifique
Distinct parasite populations infect individuals identified through passive and active case detection in a region of declining malaria transmission in southern Zambia
BACKGROUND: Substantial reductions in the burden of malaria have been documented in parts of sub-Saharan Africa, with elimination strategies and …
Article scientifique
Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy
BACKGROUND: Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the global spread of chloroquine-resistant parasites, the …
Article scientifique
Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005–2015, Ghana
BACKGROUND: Since 2005, the Government of Ghana and its partners, in concerted efforts to control malaria, scaled up the use …
Article scientifique
Ivermectin to reduce malaria transmission III. Considerations regarding regulatory and policy pathways
Vector control is a task previously relegated to products that (a) kill the mosquitoes directly at different stages (insecticides, larvicides, …
Article scientifique
Prevalence of Plasmodium falciparum and non-P. falciparum infections in a highland district in Ghana, and the influence of HIV and sickle cell disease
BACKGROUND: In the past two decades, there has been a reported decline in malaria in Ghana and the rest of …
Article scientifique
The end of a dogma: the safety of doxycycline use in young children for malaria treatment
Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance …
Article scientifique
Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
BACKGROUND: In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The …
Article scientifique
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria …
Article scientifique
Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study
BACKGROUND: Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, …
Article scientifique
Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and …
Article scientifique
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda
BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children …
Article scientifique
Assessment of the utility of a symptom-based algorithm for identifying febrile patients for malaria diagnostic testing in Senegal
BACKGROUND: Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The …