43 publication(s) trouvée(s)
Article scientifique
PopART-IBM, a highly efficient stochastic individual-based simulation model of generalised HIV epidemics developed in the context of the HPTN 071 (PopART) trial
Mathematical models are powerful tools in HIV epidemiology, producing quantitative projections of key indicators such as HIV incidence and prevalence. …
Article scientifique
Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection
The risk of tuberculosis (TB) disease is higher in individuals with recent Mycobacterium tuberculosis (M.tb) infection compared to individuals with …
Article scientifique
Modelling of malaria risk, rates, and trends: A spatiotemporal approach for identifying and targeting sub-national areas of high and low burden
While mortality from malaria continues to decline globally, incidence rates in many countries are rising. Within countries, spatial and temporal …
Article scientifique
Using a multiple-delivery-mode training approach to develop local capacity and infrastructure for advanced bioinformatics in Africa
With more microbiome studies being conducted by African-based research groups, there is an increasing demand for knowledge and skills in …
Article scientifique
Predicting lymphatic filariasis elimination in data-limited settings: A reconstructive computational framework for combining data generation and model discovery
Although there is increasing importance placed on the use of mathematical models for the effective design and management of long-term …
Article scientifique
The research and development process for multiscale models of infectious disease systems
Multiscale modelling of infectious disease systems falls within the domain of complexity science-the study of complex systems. However, what should …
Article scientifique
Interference with HIV infection of the first cell is essential for viral clearance at sub-optimal levels of drug inhibition
HIV infection can be cleared with antiretroviral drugs if they are administered before exposure, where exposure occurs at low viral …
Article scientifique
Think: Theory for Africa
Understanding the brain is one of the most challenging scientific problems faced by humanity.In addition to offering an improved understanding …
Article scientifique
Bridging the gap between HIV epidemiology and antiretroviral resistance evolution: Modelling the spread of resistance in South Africa
The scale-up of antiretroviral therapy (ART) in South Africa substantially reduced AIDS-related deaths and new HIV infections. However, its success …
Article scientifique
Ten simple rules for organizing a webinar series
International audience
Article scientifique
Designing and running an advanced Bioinformatics and genome analyses course in Tunisia
Genome data, with underlying new knowledge, are accumulating at exponential rate thanks to ever-improving sequencing technologies and the parallel development …
Article scientifique
Full-Length Envelope Analyzer (FLEA): A tool for longitudinal analysis of viral amplicons
Next generation sequencing of viral populations has advanced our understanding of viral population dynamics, the development of drug resistance, and …
Article scientifique
Strategies and opportunities for promoting bioinformatics in Zimbabwe
Overview of bioinformatics in AfricaThe establishment of the South African National Bioinformatics Institute in South Africa in the 1990s heralded …
Article scientifique
Quick tips for creating effective and impactful biological pathways using the Systems Biology Graphical Notation
Quick tips for creating effective and impactful biological pathways using the Systems Biology Graphical Notation
Article scientifique
The development and application of bioinformatics core competencies to improve bioinformatics training and education
Bioinformatics is recognized as part of the essential knowledge base of numerous career paths in biomedical research and healthcare. However, …
Article scientifique
Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy
A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use …
Article scientifique
Designing a course model for distance-based online bioinformatics training in Africa: The H3ABioNet experience
Africa is not unique in its need for basic bioinformatics training for individuals from a diverse range of academic backgrounds. …
Article scientifique
The eBioKit, a stand-alone educational platform for bioinformatics
Bioinformatics skills have become essential for many research areas; however, the availability of qualified researchers is usually lower than the …
Article scientifique
Spatial dynamics and control of a crop pathogen with mixed-mode transmission
Trade or sharing that moves infectious planting material between farms can, for vertically-transmitted plant diseases, act as a significant force …
Article scientifique
Assessing computational genomics skills: Our experience in the H3ABioNet African bioinformatics network
The H3ABioNet pan-African bioinformatics network, which is funded to support the Human Heredity and Health in Africa (H3Africa) program, has …