219 publication(s) trouvée(s)
Article scientifique
Understanding preferences for HIV care and treatment in Zambia: Evidence from a discrete choice experiment among patients who have been lost to follow-up
BACKGROUND: In public health HIV treatment programs in Africa, long-term retention remains a challenge. A number of improvement strategies exist …
Article scientifique
Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial
BACKGROUND: Antibiotic prophylaxis for contacts of meningitis cases is not recommended during outbreaks in the African meningitis belt. We assessed …
Article scientifique
Health insurance coverage with or without a nurse-led task shifting strategy for hypertension control: A pragmatic cluster randomized trial in Ghana
BACKGROUND: Poor access to care and physician shortage are major barriers to hypertension control in sub-Saharan Africa. Implementation of evidence-based …
Article scientifique
Universal versus conditional day 3 follow-up for children with non-severe unclassified fever at the community level in the Democratic Republic of the Congo: A cluster-randomized, community-based non-inferiority trial
BACKGROUND: The World Health Organization's integrated community case management (iCCM) guidelines recommend that all children presenting with uncomplicated fever and …
Article scientifique
From surviving to thriving: What evidence is needed to move early child-development interventions to scale?
Previous research has established that delivering interventions in the first 1,000 days of life improves mother-child attachment [1], contributes to …
Article scientifique
Universal versus conditional day 3 follow-up for children with non-severe unclassified fever at the community level in Ethiopia: A cluster-randomised non-inferiority trial
BACKGROUND: With declining malaria prevalence and improved use of malaria diagnostic tests, an increasing proportion of children seen by community …
Article scientifique
Two-year impact of community-based health screening and parenting groups on child development in Zambia: Follow-up to a cluster-randomized controlled trial
BACKGROUND: Early childhood interventions have potential to offset the negative impact of early adversity. We evaluated the impact of a …
Article scientifique
Integrating HIV and hypertension management in low-resource settings: Lessons from Malawi
Pragna Patel and colleagues describe the implementation of a hypertension management model for HIV-infected people in Malawi.
Article scientifique
Global child and adolescent mental health: The orphan of development assistance for health
points• One-quarter of disability-adjusted life years (DALYs) for mental disorders and substance abuse is borne by those 24 years old …
Article scientifique
What’s coming for health science and policy in 2018? Global experts look ahead in their field
PLOS Medicine's commitment to bringing research and commentary on urgent, grievous, and underaddressed health needs to an open-access platform has …
Article scientifique
Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: Findings from a multistage sampling-based survey
BACKGROUND: Survival represents the single most important indicator of successful HIV treatment. Routine monitoring fails to capture most deaths. As …
Article scientifique
The WHO 2016 verbal autopsy instrument: An international standard suitable for automated analysis by InterVA, InSilicoVA, and Tariff 2.0
BACKGROUND: Verbal autopsy (VA) is a practical method for determining probable causes of death at the population level in places …
Article scientifique
Antiretroviral therapy and population mortality: Leveraging routine national data to advance policy
Reducing mortality from HIV, tuberculosis, and malaria with effective medicines, preventing diseases with immunisations, and improving access to safe water …
Article scientifique
Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study
BACKGROUND: Substantial reductions in adult mortality have been observed in South Africa since the mid-2000s, but there has been no …
Article scientifique
Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: An evaluation from multi-country surveys and stakeholder interviews
BACKGROUND: Benzathine penicillin G (BPG) is the only recommended treatment to prevent mother-to-child transmission of syphilis. Due to recent reports …
Article scientifique
Treatment guidelines and early loss from care for people living with HIV in Cape Town, South Africa: A retrospective cohort study
BACKGROUND: South Africa has undergone multiple expansions in antiretroviral therapy (ART) eligibility from an initial CD4+ threshold of ≤200 cells/μl …
Article scientifique
The end of HIV: Still a very long way to go, but progress continues
In an Editorial accompanying PLOS Medicine's Special Issue on Advances in Prevention, Treatment and Cure of HIV/AIDS, Guest Editors Steven …
Article scientifique
Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial
BACKGROUND: Although WHO recommends viral load (VL) monitoring for those on antiretroviral therapy (ART), availability in low-income countries remains limited. …
Article scientifique
Prospects for passive immunity to prevent HIV infection
The need for better HIV prevention toolsDespite the widespread global rollout of antiretroviral therapy and its ability to reduce onward …
Article scientifique
Validity of a minimally invasive autopsy for cause of death determination in maternal deaths in Mozambique: An observational study
Despite global health efforts to reduce maternal mortality, rates continue to be unacceptably high in large parts of the world. …