210 publication(s) trouvée(s)
Article scientifique
Importance of human demographic history knowledge in genetic studies involving multi-ethnic cohorts
Paucity of data from African populations due to under-representation in human genetic studies has impeded detailed understanding of the heritable …
Article scientifique
Implementing a quality management system using good clinical laboratory practice guidelines at KEMRI-CMR to support medical research
Background: Good Clinical Laboratory Practice (GCLP) is a standard that helps ensure the quality and reliability of research data through …
Article scientifique
Evaluation of consensus method for the culture of Burkholderia pseudomallei in soil samples from Laos
Background: We have previously shown that PCR following enrichment culture is the most sensitive method to detect Burkholderia pseudomallei in …
Article scientifique
Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda
Background: Severe anaemia in children requiring hospital admission is a major public health problem in malaria-endemic Africa. Affordable methods for …
Article scientifique
Strengthening ethical community engagement in contemporary Malawi
Although community engagement is increasingly promoted in global health research to improve ethical research practice, there is sometimes a disconnect …
Autre document
Modifying Intestinal Integrity and MicroBiome in Severe Malnutrition with Legume-Based Feeds (MIMBLE 2.0): protocol for a phase II refined feed and intervention trial
Background: Changes in intestinal mucosal integrity and gut microbial balance occur in severe acute malnutrition (SAM), resulting in treatment failure …
Article scientifique
Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial
Background: Postpartum haemorrhage (PPH) is a leading cause of maternal death. The WOMAN trial showed that tranexamic acid (TXA) reduces …
Article scientifique
H3Africa: crucial importance of knowledge on human demographic history in strategies for data exploitation – an analysis of the Luhya in Webuye, Kenya population from the 1000 Genomes Project
Paucity of data from African populations has restricted understanding of the heritable human genome variation. Although under-represented in human genetic …
Article scientifique
Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baseline epidemiological observations
Background: Endemic and seasonally recurring respiratory viruses are a major cause of disease and death globally. The burden is particularly …
Article scientifique
Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC): Supporting the transition from strategy to action
In recognition of the central importance of surveillance and epidemiology in the control of antimicrobial resistance and the need to …
Article scientifique
Smartphones for community health in rural Cambodia: A feasibility study
Background: Village Malaria Workers (VMWs) are lay people trained to provide a valuable role in frontline testing and treatment of …
Article scientifique
Non-financial incentives and professional health workers’ intentions to stay in public district hospitals in Rwanda: A cross-sectional study
Background: Evidence shows that human resources represent a pillar that supports the healthcare system. As a result, retaining the health …
Article scientifique
Neonatal nursing policy and practice in Kenya: Key stakeholders and their views on task-shifting as an intervention to improve care quality.
Background: Improving the quality of facility based neonatal care is central to tackling the burden of neonatal mortality in Low …
Article scientifique
ANIMA: Association network integration for multiscale analysis
Contextual functional interpretation of -omics data derived from clinical samples is a classical and difficult problem in computational systems biology. …
Article scientifique
Evaluating the performance of tools used to call minority variants from whole genome short-read data
Background: High-throughput whole genome sequencing facilitates investigation of minority sub-populations from virus positive samples. Minority variants are useful in understanding …
Article scientifique
Detection and quantification of Anopheles gambiae sensu lato mosquito larvae in experimental aquatic habitats using environmental DNA (eDNA).
Background: Growing insecticide resistance and changes in biting and resting behavior of malaria vectors threaten efficacy of insecticide treated nets …
Article scientifique
First report of the presence of L1014S Knockdown-resistance mutation in Anopheles gambiae s.s and Anopheles coluzzii from Togo, West Africa
Background: To optimize the success of insecticide-based malaria control intervention, knowledge of the distribution of Anopheles gambiae species and insecticide …
Article scientifique
Using theories of change to design monitoring and evaluation of community engagement in research: experiences from a research institute in Malawi
Background: Evaluation of community and public engagement in research is important to deepen understanding of how engagement works and to …
Article scientifique
A hidden burden of neonatal illness? A cross-sectional study of all admissions aged less than one month across twelve Kenyan County hospitals
Background: Small and sick newborns need high quality specialised care within health facilities to address persistently high neonatal mortality in …
Article scientifique
Water source most suitable for rearing a sensitive malaria vector, Anopheles funestus in the laboratory
Background: The insecticide susceptibility status ofAnopheles funestus,one of the main malaria vectors in the Afrotropical regions, remains under-studied due to …