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Publications
7383 publication(s) trouvée(s)
Article scientifique
Novel peptides from the edible bivalve Ruditapes decussatus target apoptosis, autophagy, and FGF19-FGFR4 signaling in human cancer cell lines
Bioactive peptides have recently emerged as promising candidates for cancer treatment due to their selective cytotoxicity toward cancer cells. The …
Article scientifique
Bioinformatics approach for discovery of potential lead compound of NSP6 of SARS-CoV-2 using structure based virtual screening and molecular dynamics simulations
Non-Structural Protein 6 (NSP6) is a crucial protein for SARS-CoV-2 as it performs a vital role in the replication and …
Article scientifique
DNA barcoding and phylogenetic analysis to characterize biodiversity of some freshwater fish species in Lake Nasser and River Nile
The present study aims to provide an inventory of eight freshwater fish species that represent 6 families obtained from Lake …
Article scientifique
Adaptive identity-regularized generative adversarial networks with species-specific loss functions for enhanced fish classification and segmentation through data augmentation
Traditional fish classification systems suffer from limited training data and imbalanced datasets, particularly for rare or morphologically complex species. This …
Article scientifique
Whole genome sequencing analysis of antibiotic resistant genes of Shigella species: A systematic review and meta-analysis
BACKGROUND: In developing nations, Shigella species are the leading cause of epidemic dysentery, especially among children under five. Antibiotic resistance …
Article scientifique
Evaluation of the antidiarrheal activity of dichloromethane-methanol crude extract of the aerial parts of Croton kinondoensis (Euphorbiaceae) in Mice
BACKGROUND: Diarrhea remains a major global health concern, particularly in developing countries. Resistance to conventional antibiotics underscores the need for …
Article scientifique
A review and in silico screening of plant-derived snake venom/toxin inhibitors: ADMET, drug-likeness, and medicinal chemistry profiling
Snakebite envenomation remains a pressing global health issue, contributing to high rates of illness and death. It also imposes significant …
Article scientifique
Quorum quenching by endophytic Bacillus cereus AL1: a lactonase-based anti-virulence strategy against Pseudomonas aeruginosa
BACKGROUND: Pseudomonas aeruginosa infections are often challenging to treat due to multiple drug resistance, besides the development of biofilms and …
Article scientifique
Pathogenicity and virulence factors of Escherichia coli discovered using next generation sequencing technologies and proteomics
Escherichia coli is a gastrointestinal bacterium previously known for its commensal activities in the human digestive systems. Their occurrence in …
Article scientifique
Emergence, surge, and fading of the novel feline parvovirus Thr390Ala mutant in Egyptian cats during 2023: insights from a comprehensive full-length VP2 genetic analysis
BACKGROUND: Feline parvovirus (FPV) causes feline panleukopenia (FPL) and cerebellar ataxia (CA) in cats. to date, only two complete Egyptian …
Article scientifique
Targeting RNA-binding proteins with small molecules: perspectives and challenges
RNA-binding proteins (RBPs) play critical roles in numerous biological processes because they regulate RNA function by directly interacting with RNA …
Article scientifique
Cancer-derived exosomes: mediators of immune crosstalk and emerging targets for immunotherapy
Exosomes, nanoscale extracellular vesicles secreted by various cell types, play pivotal roles in intercellular communication. In cancer, tumor-derived exosomes-referred to …
Article scientifique
Exosome engineering for targeted therapy of brain-infecting pathogens: molecular tools, delivery platforms, and translational advances
Central nervous system (CNS) infections caused by pathogens such as HIV, Herpes simplex virus, Cryptococcus neoformans, and Toxoplasma gondii remain …
Article scientifique
Integrating artificial intelligence with nanodiagnostics for early detection and precision management of neurodegenerative diseases
BACKGROUND: Neurodegenerative diseases—including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS)—as well as autoimmune disorders with neurodegenerative features such as multiple …
Article scientifique
The transforming role of wharton’s jelly mesenchymal stem cell-derived exosomes for diabetic foot ulcer healing: a randomized controlled clinical trial
BACKGROUND: Diabetic foot ulcers (DFUs), which have high rates of recurrence, amputation, and death, are a significant complication in the …
Article scientifique
Polygenic risk scores and Parkinson’s disease in South Africa: Moving towards ancestry-informed disease prediction
Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder with environmental and genetic influences. Using genotyping array data of 661 …
Article scientifique
One-week adjuvant breast radiotherapy: Retrospective outcomes from a Johannesburg oncology unit
Background: A 1-week, ultra-hypofractionated adjuvant radiation regimen has been found to be non-inferior to the standard 3-week regimen in women …
Article scientifique
Determinants of diphtheria outbreaks and predictors of outcomes; lessons learnt from 2025 outbreak in Imo State, Nigeria
Abstract Diphtheria is a potentially fatal infectious that presents mostly with respiratory symptoms in which an exotoxin produced by the …
Article scientifique
Validation of a Lip Asymmetry Scale and Determination of Lip Asymmetry Associated Factors Among Children Following Primary Unilateral Cleft Lip Repair at Corsu Rehabilitation Hospital, Uganda
Article scientifique
Epigenetic and microRNA Signatures as Predictive Biomarkers in HCV Genotype 4-Induced Liver Cirrhosis and HCC