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Publications
7377 publication(s) trouvée(s)
Article scientifique
Clinicopathological and molecular subtypes of breast cancer in the Eastern Cape, South Africa: A two-year retrospective study
BACKGROUND: Breast cancer (BC) is the most common cancer in women worldwide and the most frequent cause of cancer death …
Article scientifique
Immune cell diversity and regenerative markers reveal interactions among macrophages, rodlet cells, and stem cells in the kidney of Poecilia sphenops
The kidneys of molly fish (Poecilia sphenops) exhibit complex immune and cellular activities, which are crucial for maintaining renal function …
Article scientifique
Optimizing a rapid tissue culture method for steviol glycoside production from Stevia rebaudiana to address Egypt’s sugar deficit
Egypt has encountered a significant sugar scarcity since 2023, due to a water crisis, which has reduced local sugar production, …
Article scientifique
Emergence of extensively drug-resistant Klebsiella pneumoniae from broiler chickens and clinical samples in Egypt
BACKGROUND: Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogen belonging to Enterobacteriaceae family. It is present in the intestinal tract …
Article scientifique
Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar
BACKGROUND: The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid …
Article scientifique
Mutational spectrum of BRCA genes in Egyptian patients with breast cancer
The rising incidence of breast cancer (BC) among Egyptian females with a mortality rate of 11% and younger age at …
Article scientifique
Streamlined analytical strategy using resonance Rayleigh scattering signal amplification for nanoscale quantification of rasagiline in tablets with content assessment
Rasagiline (RSG), a prevalent drug for Parkinson's disease, is classified as a monoamine oxidase inhibitor. These drugs operate by elevating …
Article scientifique
Wide-scale geographical analysis of genetic ancestry in the South African Coloured population
BACKGROUND: The South African Coloured (SAC) population, a prominent admixed population in South Africa, reflects centuries of migration, admixture, and …
Article scientifique
High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach
BACKGROUND: Escherichia coli is an important cause of neonatal sepsis and the third most prevalent cause of neonatal infection in …
Article scientifique
Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation
Pseudomonas aeruginosa employs N-acylated L-homoserine lactones (AHLs) as autoinducers (AIs) for quorum sensing, which in the end is responsible for …
Article scientifique
mTOR pathway targeted inhibition via Rapamycin-loaded PLGA nanoparticles for enhanced bladder cancer therapy
Bladder cancer remains a major clinical challenge due to high recurrence rates, metastatic potential, and the development of drug resistance …
Article scientifique
Healthcare workers’ priorities of WHO snakebite strategic objectives for the control and prevention of snakebite envenoming in Ghana: A machine learning statistical design of experiment modeling
BACKGROUND: Snakebite is a severe neglected tropical disease (NTD) that affects 2.5 million people each year, resulting in the deaths …
Article scientifique
Evidence of early genomic selection in Holstein Friesian across African and European ecosystems
BACKGROUND: The Holstein Friesian (HF) cattle breed is the most dominant breed in commercial dairy farming worldwide and managed in …
Article scientifique
Emerging antibiotic resistance in Vibrio cholerae: a study of cholera prevalence and resistance patterns in Zambia’s Copperbelt Province
INTRODUCTION: Cholera remains a significant public health challenge in Zambia, particularly in the Copperbelt Province, where antibiotic-resistant Vibrio cholerae strains …
Article scientifique
Antimicrobial effect of curcumin, alone or in combination with black pepper, against foodborne pathogens in vacuum-packed ground mutton
Finding healthy, effective, safe, and affordable natural alternatives to synthetic preservatives for extending the shelf life of meat products has …
Article scientifique
Genomic insights into five selected multidrug-resistant Pseudomonas aeruginosa isolated from Sodwana Bay, South Africa
Pseudomonas aeruginosa ( P. aeruginosa ) is a common environmental organism and the leading cause of opportunistic human diseases. Its …
Article scientifique
Unlocking the African bioeconomy and strengthening biodiversity conservation through genomics and bioinformatics
The African BioGenome Project (AfricaBP) is a Pan-African initiative aimed at improving food systems and biodiversity conservation through genomics while …
Article scientifique
Treatment of non-small cell lung cancer using chem-bioinformatics-driven engineering of exosomal cargo-vehicle for telmisartan and pioglitazone targeted-delivery
The activation of the PPARG transcription factor is linked to reduced non-small cell lung cancer (NSCLC) growth. Bioinformatics, cheminformatics, and …
Article scientifique
Network meta-analysis of randomized control trials evaluating the effectiveness of various probiotic formulations in patients with type 2 diabetes mellitus
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a global health concern with a rising prevalence. Recent studies indicate that the …
Article scientifique
Context-Seq: CRISPR-Cas9 targeted nanopore sequencing for transmission dynamics of antimicrobial resistance
Abstract Precisely understanding how and to what extent antimicrobial resistance (AMR) is exchanged between animals and humans is needed to …