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HIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africa

Article scientifique 2018 Anglais

Résumé

BACKGROUND: Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TG) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations. METHODS: Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models. FINDINGS: =45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies. INTERPRETATION: Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

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Ekoru, K., Young, E. H., Dillon, D., Gurdasani, D., Stehouwer, N., Faurholt‐Jepsen, D., Levitt, N., Crowther, N. J., Nyirenda, M., Njelekela, M., Ramaiya, K., Nyan, O., Adewole, O., Anastos, K., Compostella, C., Dave, J. A., Fourie, C. M. T., Friis, H., Kruger, I. M., Longenecker, C. T., Maher, D., Mutimura, E., Ndhlovu, C. E., PrayGod, G., Yone, E. P., Pujades‐Rodríguez, M., Range, N., Sani, M. U., Sanusi, M., Schutte, A. E., Sliwa, K., Tien, P. C., Vorster, E., Walsh, C. M., Gareta, D., Mashili, F., Sobngwi, E., Adebamowo, C., Kamali, A., Seeley, J., Smeeth, L., Pillay, D., Motala, A. A., Kaleebu, P., & Sandhu, M. S. (2018). HIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africa. Global Health. https://doi.org/10.1017/gheg.2018.7

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Auteur(s)

Kenneth Ekoru E. H. Young David Dillon Deepti Gurdasani Nathan Stehouwer Daniel Faurholt‐Jepsen Naomi Levitt Nigel J. Crowther Moffat Nyirenda Marina Njelekela Kaushik Ramaiya O. Nyan Olufemi Adewole Kathryn Anastos Chiara Compostella Joel A. Dave Carla Maria Theresia Fourie Henrik Friis Iolanthé M. Kruger Chris T. Longenecker Dermot Maher Eugene Mutimura Chiratidzo E. Ndhlovu George PrayGod E.W. Pefura Yone Mar Pujades‐Rodríguez Nyagosya Range Mahmoud U. Sani M. Sanusi Aletta E. Schutte Karen Sliwa Phyllis C. Tien E. Vorster Corinna M. Walsh Dickman Gareta Fredirick Mashili Eugène Sobngwi Clement Adebamowo A. Kamali Janet Seeley Liam Smeeth Deenan Pillay Ayesha A. Motala Pontiano Kaleebu Manjinder S. Sandhu

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