{# Audit 04/10/2026 : « autre » n'est pas un code de langue ; SPHAERO n'est pas l'éditeur des documents qu'elle héberge ou référence. #} {# citation_pdf_url doit mener à un PDF : un lien vers une page DOI est pénalisé par Google Scholar (avant : tout lien externe). #}
Accès ouvert · CC BY

Pooled analysis of PCV13 efficacy from controlled human infection trials in Malawi and the UK

Article scientifique 2026 Anglais

Résumé

We conducted the first pooled analysis of two randomised controlled vaccine trials on experimental pneumococcal serotype 6B carriage, registered in Malawi (PACTR202008503507113) and the UK (ISRCTN45340436). This post-hoc exploratory study examined the sex-based differences in carriage, vaccine efficacy and vaccine-induced responses. PCV-13 reduced colonisation by 76% (p < 0.001) with non-significant interaction by sex (RR = 1.549, p = 0.413). Females showed a higher carriage rate than males (28% vs. 19%, p = 0.066). Baseline anti-6B Capsular Polysaccharide Immunoglobulin G (IgG) titres were higher in females, significantly in Malawi (2.62 µg/ml vs males 2.05 µg/ml, p = 0.015). Post-vaccination titres did not differ by sex. The pooled fold change in IgG pre-post vaccination, was higher in vaccinated females (5.47 vs 3.30, p = 0.053). This analysis demonstrates the utility and challenges of integrating CHIM data between diverse settings to evaluate vaccine efficacy, describe inter-setting differences, investigate biological and immunological factors influencing protection against pneumococcal carriage and ultimately inform future vaccine development strategies.

Citer ce document

Kudowa, E., Tembo, G., Chirwa, A. E., Chikaonda, T., Muyaya, A., Makhaza, L., Nsomba, E., Galafa, B., Thole, F., Ndaferankhande, J. M., Chimgoneko, L., Toto, N., Dula, D., Morton, B., Pennington, S. H., Hyder-Wright, A. D., Collins, A. M., Mitsi, E., Ferreira, D. M., Gordon, S. B., Henrion, M., consortia, O. B. O. M. A. E., Alderson, M. R., Antoine, S., Bailey, C. R., Bogaert, D., Brown, J., Burr, S. E., Jonge, M. L. D., Doherty, K., Goldblatt, D., Gondwe, J., Gooding, K., Grigg, J., Harawa, T., Heyderman, R., Hinds, J., Jochems, S., Kapumba, B. M., Kaudzu, V., KNELLER, R. W., Malley, R., Mallewa, J., Manda‐Taylor, L., Mangani, E., Mayuni, M., Mwandumba, H., Ngwira, B., Mwenechanya, P., Parker, M., Pollard, A., Reuben, M., Gomes, G. C., Weiser, J. N., Jambo, K., Nyazika, T. K., Mkutumula, M., Chipwete, M., consortia, E., Bailey, C., Beall, B., Bentley, S., Bogaert, D., Campo, J. D., Clarke, S., Cleary, D., Finn, A. H., Gessner, B., Hales, C., Hamon, M., HEYDERMAN, R., Kiyono, H., Leong, S., Lipsitch, M., Mann, A., Mina, M., Miyaji, E., Nakaya, H., Napolitani, G., Neill, D., Netea, M., Oggioni, M. R., Openshaw, P., Peterson, F., Plummer, S., Kwambana-Adams, B., Roberts, A., Saleem, I., Schlitzer, A., Shalek, A., Tobery, T., Tregoning, J., & Weiser, J. (2026). Pooled analysis of PCV13 efficacy from controlled human infection trials in Malawi and the UK. npj Vaccines. https://doi.org/10.1038/s41541-026-01381-4

Exporter : BibTeX · RIS (Zotero, Mendeley, EndNote)

Accès au document

Texte intégral en lecture en ligne, réservé aux abonnés SPHAERO et aux membres de l'institution. Se connecter

Voir l'article sur le site de la revue

Licence et provenance

Licence : CC BY

Notice moissonnée depuis OpenAlex le 30/09/2026. Le document reste hébergé par sa source.
Voir le document à la source →

Auteur(s)

Evaristar Kudowa Godwin Tembo Anthony Emeritus Chirwa Tarsizio Chikaonda Alfred Muyaya Lumbani Makhaza Edna Nsomba Bridgette Galafa Faith Thole John M. Ndaferankhande Lorensio Chimgoneko Neema Toto Dingase Dula Ben Morton Shaun H. Pennington Angela D. Hyder-Wright Andrea M. Collins Elena Mitsi Daniela M. Ferreira Stephen B. Gordon Marc Henrion On behalf of MARVELS and EHPC consortia Mark R. Alderson Sandra Antoine Christopher R. Bailey Debbie Bogaert Jeremy Brown Sarah E. Burr Marien L. De Jonge Klara Doherty David Goldblatt Joel Gondwe Kate Gooding Jonathan Grigg Tina Harawa Rob Heyderman Jason Hinds Simon Jochems Blessings M. Kapumba Vella Kaudzu ROBERT W. KNELLER Richard Malley Jane Mallewa Lucinda Manda‐Taylor Edward Mangani Mphatso Mayuni Henry Mwandumba Brian Ngwira Percy Mwenechanya Mike Parker Andrew Pollard Modesta Reuben Gabriela Carvalho Gomes Jeffrey N. Weiser Kondwani Jambo Tinashe K. Nyazika Maureen Mkutumula Maurice Chipwete EHPC consortia C. Bailey Bernard Beall Stephen Bentley Debby Bogaert Joe De Campo Stuart Clarke David Cleary Adam H.R. Finn Brad Gessner Caz Hales Mélanie Hamon Robert HEYDERMAN Hiroshi Kiyono Samuel Leong Marc Lipsitch Alex Mann Michael Mina Eliane Miyaji Helder Nakaya Giorgio Napolitani Daniel Neill Mihai Netea Marco R. Oggioni Peter Openshaw Fernanda Peterson Sue Plummer Brenda Kwambana-Adams Adam Roberts Imran Saleem Andreas Schlitzer Alex Shalek Timothy Tobery John Tregoning Jeffrey Weiser

Statistiques

Consultations : 2

Téléchargements : 0