NSAIDs, SARS CoV-2 ORF Proteins, Caspases, and CARD14: Solving the Mystery of COVID-19 and Beyond

Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In this manuscript we further build on our previous suggested potential beneficial effects of using NSAIDs as first choice drugs in COVID-19 management while discussing the role that SARS CoV-2 ORF proteins induced caspases play in the pathophysiology of SARS CoV-2 infection. Moreover, we postulate that CARD 14, a caspase recruitment domain-containing protein of the membrane-associated guanylate kinases family, mutations might share a role in development of severe and critical COVID-19.