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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Article scientifique 2017 Anglais

Résumé

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

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Adema, C., Hillier, L., Jones, C., Loker, E., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., Amaral, L., Arican-Goktas, H., Geraldo, J., Baba, E., Baron, O., Bayne, C., Bickham-Wright, U., Biggar, K., Blouin, M., Bonning, B., Botka, C., Bridger, J., Buckley, K., Buddenborg, S., Caldeira, R., Carleton, J., Carvalho, O., Castillo, M., Chalmers, I., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R., Cuesta-Astroz, Y., Cummins, S., Stefano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S., Geusz, M., Geyer, K., Giraldo-Calderón, G., Gomes, M., Gordy, M., Gourbal, B., Grunau, C., Hanington, P., Hoffmann, K., Hughes, D., Humphries, J., Jackson, D., Jannotti-Passos, L., Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J., Kohn, A., Lawson, D., Lawton, S., Liang, D., Limpanont, Y., Liu, S., Lockyer, A., Lovato, T., Ludolf, F., Magrini, V., McManus, D., Medina, M., Misra, M., Mitta, G., Mkoji, G., Montague, M., Hernandez, C., Moroz, L., Munoz-Torres, M., Niazi, U., Noble, L., Oliveira, F., Pais, F., Papenfuss, A., Peace, R., Peña, J., Pila, E., Quelais, T., Raney, B., Rast, J., Rollinson, D., Rosse, I., Rotgans, B., Routledge, E., Ryan, K. (2017). Whole genome analysis of a schistosomiasis-transmitting freshwater snail. https://doi.org/10.1038/ncomms15451

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Auteur(s)

Coen M. Adema LaDeana W. Hillier Catherine S. Jones Eric S. Loker Matty Knight Patrick Minx Guilherme Oliveira Nithya Raghavan Andrew M. Shedlock Laurence Rodrigues do Amaral Halime D. Arican-Goktas Juliana Assis Geraldo Elio H. Baba Olga Lucia Baron Christopher J. Bayne Utibe Bickham-Wright Kyle K. Biggar Michael S. Blouin Bryony C. Bonning Chris Botka Joanna M. Bridger Katherine M. Buckley Sarah K. Buddenborg Roberta Lima Caldeira Julia B. Carleton Omar S Carvalho Maria G. Castillo Iain W. Chalmers Mikkel Christensens Sandra W. Clifton Céline Cosseau Christine Coustau Richard M. Cripps Yesid Cuesta-Astroz Scott F. Cummins Leon Di Stefano Nathalie Dinguirard David Duval Scott Emrich Cédric Feschotte René Feyereisen Peter Fitzgerald Catrina Fronick Lucinda A. Fulton Richard Galinier Sandra Grossi Gava Michael E. Geusz Kathrin K. Geyer Gloria I. Giraldo-Calderón Matheus de Souza Gomes Michelle A. Gordy Benjamin Gourbal Christoph Grunau Patrick C. Hanington Karl F. Hoffmann Daniel Hughes Judith Humphries Daniel J. Jackson Liana K. Jannotti-Passos Wander de Jesus Jeremias Susan Jobling Bishoy Kamel Aurélie Kapusta Satwant Kaur Joris M. Koene Andrea B. Kohn Daniel Lawson Scott P. Lawton Di Liang Yanin Limpanont Sijun Liu Anne E. Lockyer TyAnna L. Lovato Fernanda Ludolf Vincent Magrini Donald P. McManus Monica Medina Milind Misra Guillaume Mitta Gerald M. Mkoji Michael J. Montague Cesar Montelongo Hernandez Leonid L. Moroz Monica C. Munoz-Torres Umar Niazi Leslie R. Noble Francislon S. Oliveira Fabiano Pais Anthony T. Papenfuss Rob Peace Janeth J. Peña Emmanuel A. Pila Titouan Quelais Brian J. Raney Jonathan P. Rast David Rollinson Izinara Cruz Rosse Bronwyn A. Rotgans Edwin J. Routledge Kathryn M. Ryan

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