Resveratrol-Zinc Nanoparticles for COVID-19 Management: Potential Other Inflammatory, Immunologic and Oncologic Benefits.

A peer reviewed published version is found here: https://www.sciencedirect.com/science/article/pii/S075333222100411X?via%3Dihub In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Alternatively, pterostilbene-zinc combination might be also considered for clinical trials. We recommend conducting prompt clinical trials to assess the potential of the suggested combinations as a monotherapy for mild COVID-19 with a potential to prevent its progression to moderate-severe disease for which we also recommend its trial as an adjuvant therapy. Furthermore, he suggested combinations might also possess a pharmacotherapeutic potential that exceeds COVID-19 to various inflammatory, immunologic, and oncologic diseases.