Antibiogram of Pseudomonas Aeruginosa Isolates from Patients with Diabetic Septic Wounds Attending Two Public Hospitals in Khartoum, Sudan.

Abstract Objectives: Treating infections caused by Pseudomonas aeruginosa is challenging. In addition to its intrinsic ability to develop resistance to multiple classes of antibiotics, it also produces Extended Spectrum β lactamases (ESBL). This study aimed to determine the antimicrobial susceptibility pattern and to determine the ESBL status among the P. aeruginosa isolates from patients at two public military hospitals in Khartoum, Sudan.Results: A total of 34 isolates of P. aeruginosa obtained from patients with diabetic septic foot wounds were tested for their antibiotic sensitivity patterns. Resistance occurred most commonly to Ceftazidime (35%), followed by Ciprofloxacin (20.6%) and Piperacillin (14.7%). We found that 17.6% of the P. aeruginosa isolates were ESBL producers and all of these isolates were sensitive to Meropenem. The chi-squared test showed a significant association between the ESBL status and antimicrobial resistance to Amikacin, Ceftazidime, and Piperacillin. The independent T-test showed a significant association between the ESBL status and resistance to Cefepime. The presence of drug-resistant P. aeruginosa poses a serious health problem. This study suggests sparing the Carbapenems for the ESBL producing P. aeruginosa in our setting. Our findings highlight the need for effective surveillance and antibiogram-guided antibiotic prescription.