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Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages

Article scientifique 2022 Anglais

Résumé

Abstract The SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern (VOC) and its sub-lineages (including BA.2, BA.4, BA.5, BA.2.12.1) contain spike mutations that confer high level resistance to neutralizing antibodies. The NVX-CoV2373 vaccine, a protein nanoparticle vaccine, has value in countries with constrained cold-chain requirements. Here we report neutralizing titers following two or three doses of NVX-CoV2373. We show that after two doses, Omicron sub-lineages BA.1 and BA.4/BA.5 were resistant to neutralization by 72% (21/29) and 59% (17/29) of samples. However, after a third dose of NVX-CoV2373, we observed high titers against Omicron BA.1 (GMT: 1,197) and BA.4/BA.5 (GMT: 582), with responses similar in magnitude to those triggered by three doses of an mRNA vaccine.These data are of particular relevance as BA.4/BA.5 is dominating in multiple locations, and highlight the potential utility of the NVX-CoV2373 vaccine as a booster in resource-limited environments.

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Bhiman, J., Richardson, S., Lambson, B., Kgagudi, P., Mzindle, N., Kaldine, H., Crowther, C., Gray, G., Bekker, L., Shinde, V., Bennett, C., Glenn, G., Madhi, S., Moore, P., Koen, A., Fairlie, L., Fouche, L., Bhorat, Q., Dheda, K., Tameris, M., Masilela, M., Hoosain, Z., Singh, N., Hanley, S., Archary, M., Louw, C., Grobbelaar, C., Lalloo, U., Joseph, N., Kruger, G. (2022). Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages. https://doi.org/10.21203/rs.3.rs-2048259/v1

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Auteur(s)

Jinal N. Bhiman Simone I. Richardson Bronwen E. Lambson Prudence Kgagudi Nonkululeko Mzindle Haajira Kaldine Carol Crowther Glenda Gray Linda‐Gail Bekker Vivek Shinde Chijioke Bennett Gregory M. Glenn Shabir A. Madhi Penny L. Moore Anthonet Koen Lee Fairlie Leon Fouche Qasim Bhorat Keertan Dheda Michèle Tameris Mduduzi Masilela Zaheer Hoosain Nishanta Singh Sherika Hanley Moherndran Archary Cheryl Louw Coert Grobbelaar Umesh Lalloo Natasha Joseph Gertruida Kruger

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