Epidemiology of Chronic Myeloid Leukemia in Tunisia

Chronic myeloid leukemia (CML) is a rare clonal myeloproliferatives disorder characterized by enhanced proliferative capacity and prolonged survival of hematpoietic stem cells.The pathogenesis of CML is driven by a bcr-abl fusion oncoprotein formed by a balanced translocation between chromosomes 9 and 22. Prevalence rate of CML has increased by use of tyrosine kinase inhibitors that transformed CML into a chronic disease.