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Plasmablastic lymphoma in Malawi

Article scientifique 2018 Anglais

Résumé

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24-79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.

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Zuze, T., Painschab, M., Séguin, R., Kudowa, E., Kaimila, B., Kasonkanji, E., Tomoka, T., Dhungel, B., Mulenga, M., Chikasema, M., Tewete, B., Ntangwanika, A., Chiyoyola, S., Chimzimu, F., Kampani, C., Krysiak, R., Montgomery, N., Fedoriw, Y., Gopal, S. (2018). Plasmablastic lymphoma in Malawi. https://doi.org/10.1186/s13027-018-0195-4

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Auteur(s)

Takondwa Zuze Matthew Painschab Ryan Séguin Evarista Kudowa Bongani Kaimila Edwards Kasonkanji Tamiwe Tomoka Bal M. Dhungel Maurice Mulenga Maria Chikasema Blessings Tewete Asekanadziwa Ntangwanika Sarah Chiyoyola Fred Chimzimu Coxcilly Kampani Robert Krysiak Nathan D. Montgomery Yuri Fedoriw Satish Gopal

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