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Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis

Article scientifique 2018 Anglais

Résumé

We investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral healthcare facilities in six African countries, prior to assessment for TB disease. We then evaluated the concentrations of 12 biomarkers in stored QuantiFERON supernatants using the Luminex platform. Based on laboratory, clinical and radiological findings and a pre-established algorithm, participants were classified as TB disease or other respiratory diseases(ORD). Of the 514 individuals included in the study, 179(34.8%) had TB disease, 274(51.5%) had ORD and 61(11.5%) had an uncertain diagnosis. A biosignature comprising unstimulated IFN-γ, MIP-1β, TGF-α and antigen-specific levels of TGF-α and VEGF, identified on a training sample set (n = 311), validated by diagnosing TB disease in the test set (n = 134) with an AUC of 0.81(95% CI, 0.76-0.86), corresponding to a sensitivity of 64.2%(95% CI, 49.7-76.5%) and specificity of 82.7%(95% CI, 72.4-89.9%). Host biomarkers detected in QuantiFERON supernatants can contribute to the diagnosis of active TB disease amongst people presenting with symptoms requiring investigation for TB disease, regardless of HIV status or ethnicity in Africa.

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Chegou, N. N., Sutherland, J. S., Namuganga, A. R., Corstjens, P. L. A. M., Geluk, A., Gebremichael, G., Mendy, J., Malherbe, S. T., Stanley, K., Spuy, G. V. D., Kriel, M., Loxton, A. G., Kriel, B., Simukonda, F., Bekele, Y., Sheehama, J., Nelongo, J. N., Vyver, M. V. D., Gebrexabher, A., Hailu, H., Esterhuyse, M. M., Rosenkrands, I., Aagard, C., Kidd, M., Kassa, D., Mihret, A., Howe, R., Cliff, J. M., Crampin, A. C., Mayanja‐Kizza, H., Kaufmann, S. H. E., Dockrell, H. M., Ottenhoff, T. H. M., Walzl, G., McAnda, S., Owolabi, O., Sillah, A. K., Gindeh, A., Donkor, S., Togun, T., Ota, M. O. C., Muzanye, G., Nsereko, M., Peters, P., Fat, E. M. T. K., Dood, C. J. D., Franken, K. L. M. C., Schip, J. J. V. D. P.-V., Gebrezgeabher, A., Mesfin, G., Belay, Y., Alemayehu, Y., Amberbir, A., Chilongo, F., Houben, R. M. G. J., Tessema, B., Yamuah, L., Amutenya, F. N., Monye, L., & Iipinge, S. (2018). Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis. Scientific Reports. https://doi.org/10.1038/s41598-018-20855-7

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Auteur(s)

Novel N. Chegou Jayne S. Sutherland Anna Ritah Namuganga Paul L. A. M. Corstjens Annemieke Geluk Gebremedhin Gebremichael Joseph Mendy Stephanus T. Malherbe Kim Stanley Gian van der Spuy Magdalena Kriel André G. Loxton Belinda Kriel Felanji Simukonda Yonas Bekele Jacob Sheehama Josefina N. Nelongo Marieta van der Vyver Atsbeha Gebrexabher Habteyes Hailu Maria M. Esterhuyse Ida Rosenkrands Claus Aagard Martin Kidd Desta Kassa Adane Mihret Rawleigh Howe Jacqueline M. Cliff Amelia C. Crampin Harriet Mayanja‐Kizza Stefan H. E. Kaufmann Hazel M. Dockrell Tom H. M. Ottenhoff Gerhard Walzl Shirley McAnda Olumuyiwa Owolabi Abdou K. Sillah Awa Gindeh Simon Donkor Toyin Togun Martin O. C. Ota Grace Muzanye Mary Nsereko Pierre Peters Elisa M. Tjon Kon Fat Claudia J. de Dood Kees L. M. C. Franken Jolien J. van der Ploeg-van Schip Atsbeha Gebrezgeabher Getnet Mesfin Yohannes Belay Yodit Alemayehu Alemayehu Amberbir Femia Chilongo Rein M G J Houben Bamlak Tessema Lawrence Yamuah Faustina N. Amutenya Lidia Monye Scholastica Iipinge

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