Use of Topical Berberine to Manage Premature Ejaculation and/or Erectile Dysfunction: Restoration of Endothelial Homeostasis.

Premature ejaculation and erectile dysfunction are affecting millions of patients all over the world and the quest for novel and safe drugs to manage either or both diseases is considered of great importance. Topical use of the herbal extract berberine might provide potential cure through restoration of endothelial homeostasis that is disturbed in both diseases as well as numerous other mechanisms as described in this manuscript and the author is the inventor and one of the holders of an internationally registered copyright to use berberine topically for management of sexual disorders.