Clinical and molecular characteristics of fructose 1, 6 bisphosphatase deficiency in 6 Egyptian patients and two common variants
Article scientifique
Accès ouvert
Solaf Mohamed Elsayed, Radwa Mahmoud, Yasmeen Abdelaziz Fereig
BACKGROUND: Fructose 1, 6 bisphosphatase (FBPase) deficiency is a rare autosomal recessive disease caused by mutations in the FBP1 gene. Symptoms of this disease are …
Insecticide resistance and malaria transmission indicators in Anopheles gambiae s.l. in Bobo-Dioulasso, Burkina Faso: implications for vector control strategies
Article scientifique
Accès ouvert
Miriam Félicité Amara, Moussa Namountougou, Hamadou Konaté
BACKGROUND: In the context of intensified malaria control efforts in Burkina Faso, this study assessed i) the insecticide resistance status of Anopheles gambiae sensu lato …
Characterization and in vitro antibacterial activity of silver nanoparticles biosynthesized using phytophthora infestans biomass
Article scientifique
Accès ouvert
Jebel Haji Mahamud, Abebe Belay Gemta, Alemu Kebede Hordofa
Abstract This study investigated the synthesis and characterization of biogenic silver nanoparticles (AgNPs) using biomass from Phytophthora infestans as a reducing and stabilizing agent. Fungal …
A scoping review of antimalarial drug resistance markers in Kenya (1987–2022): toward a National Surveillance Framework and Data Repository
Article scientifique
Accès ouvert
Kevin Wamae, John B. Magudha, Emmanuel Asiimwe
The identification of genetic markers has revolutionized the assessment of antimalarial drug resistance. Tracking the molecular markers of resistance emerged as a valuable tool over …
Genetic insights into acute lymphoblastic leukemia: the role of MDR1 and IL18 polymorphisms in Egyptian children
Article scientifique
Accès ouvert
Ali Nabeel Mahdi, Afaf Elsaid, Maha Abdelmoneim Mohammed
BACKGROUND: The most prevalent cancer in pediatric is acute lymphoblastic leukemia (ALL). The multidrug resistance gene (MDR1) encodes the membrane transport protein P-glycoprotein (P-gp), which …
Diagnostic and therapeutic potential of microRNAs and long noncoding RNAs in the molecular mechanisms of Alzheimer disease
Article scientifique
Accès ouvert
Omar Kashif, Mohamed Said
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by complex molecular mechanism, including amyloid-beta (Aβ) plaque accumulation, Tau protein hyperphosphorylation, oxidative stress and …
A systematic review of Astragalus plants in the septentrional Algerian Sahara
Article scientifique
Accès ouvert
Aicha Tedjani, Manel Azzi, Nouhad Amina Righi
Background The flora of the septentrional Algerian Sahara stands out for its remarkable resilience in the face of drought and salinity, offering a valuable resource …
A qualitative analysis exploring barriers and enablers to distribution, delivery, and access to COVID-19 vaccines in Botswana
Article scientifique
Accès ouvert
John Thato Tlhakanelo, John E. Ataguba, Vincent Pagiwa
Introduction: The COVID-19 pandemic highlighted pre-existing weaknesses, revealing deep-rooted issues in infrastructure, access, and resource allocation that have long impeded African countries' ability to effectively …
Exploring the spirituality and academic resilience among university undergraduate students
Article scientifique
Accès ouvert
Thuto G. Lehihi, Wandile Fundo Tsabedze, Choja Oduaran
Introduction Spirituality has been recognized as a potential coping mechanism and source of strength for some students. However, its relationship with academic resilience remains underexplored, …
Morphology, molecular phylogeny and record verification of Sarcophaga ruficornis Fabricius (Diptera: Sarcophagidae) from Egypt
Article scientifique
Accès ouvert
Gawhara M. M. Abu El-Hassan, Reham H. Abo El-Ela, Rabab Fathy Sawaby
In forensic entomology, accurate species identification is essential for calculating the exact minimum postmortem interval (minPMI), as insect developmental rates are highly species-specific. Sarcophaga (Liopygia) …
Novel metaheuristic optimized latent diffusion framework for automated oral disease detection in public health screening
Article scientifique
Accès ouvert
Marwa Sabry, Mostafa Elbaz, Waleed Obaid Alzabni
Automated oral disease detection systems face significant challenges from degraded radiographic imaging quality and limited pathological training data, particularly for rare conditions in public health …
Supportive care needs and challenges experienced by women diagnosed with breast cancer in Kumasi, Ghana: A qualitative exploratory study
Article scientifique
Accès ouvert
Abigail Owusu Sekyere, Merri Iddrisu, Hadiru Iddris Mumuni
INTRODUCTION: Globally, breast cancer (BC) remains the main cause of illness and death among women. A diagnosis with BC can be emotionally devastating and draining …
Induction of high numbers of Treg cells post treatment with anti-IL-2/IL-2 complex associates with alleviation of experimental psoriasis-like skin inflammation
Article scientifique
Accès ouvert
Samar Salman, Sohaila Mohamed Khalil, Amany Mohammad Abdel-Latif
Abstract Background Psoriasis is a prevalent autoimmune skin disorder; however, the mechanism of its pathogenesis remains fully understood. The imbalance of regulatory T (T reg …
Ecotoxicological impact of mosquitocidal jasmine-based oils nanoemulsion on Nile tilapia fish Oreochromis niloticus
Article scientifique
Accès ouvert
Reham E. Muhammed, Mohamed A. Al-Zahaby, Gamila A. M. Kotb
Nanoemulsion technology has become a promising approach for improving stability and bioavailability of natural products, providing more efficient and eco-friendly biocides. Jasmine oil, derived from …
Transition rates to schizophrenia and early intervention effectiveness in substance-induced and brief psychotic disorders: a randomized controlled trial
Article scientifique
Accès ouvert
Mohamed Ahmed Abouzed, Amgad Ahmed Meshref Gabr, Mohamed Elsheikh
This multisite, prospective randomized controlled trial examined transition rates to schizophrenia in individuals with recent-onset substance-induced psychotic disorder (SIPD) or brief psychotic disorder (BPD), and …
Virological failure in a pediatric cohort on a dolutegravir based regimen: a retrospective study in northwest Ethiopia, 2017–2023
Article scientifique
Accès ouvert
Woretaw Sisay Zewdu, Mulugeta Molla Zeleke, Yared Andargie Ferede
Introduction Despite the fact that antiretroviral therapy (ART) has reduced HIV/AIDS-related morbidity and mortality, pediatrics treatment failure remains a global concern. As a result, this …
Genomic characteristics of performance traits and adaptation to heat stress in desert Barki sheep
Article scientifique
Accès ouvert
A. M. Aboul-Naga, Hamdy Abdel-Shafy, Sherif Melak
The Barki sheep is well adapted to desert conditions with intense solar radiation, low precipitation, and feed shortages. This review highlights advances in the genomic …
Physicochemical and cooking properties of six pigeon pea (Cajanus cajan L) genotypes from Malawi
Article scientifique
Accès ouvert
Tamara Tumasile Machinjili, Vernon H. Kabambe, Agnes Mwangwela
Introduction Pigeon pea ( Cajanus cajan ) is a vital protein source in southern Malawi, yet the relationship between seed coat characteristics and cooking quality …
Low occurrence and clonal relatedness of multi-drug resistant Escherichia coli carrying transmissible colistin resistance mcr-1 genes in Ugandan poultry
Article scientifique
Accès ouvert
Martin Wainaina, Dickson Ndoboli, Dreck Ayebare
Introduction Colistin resistance is an emerging global health concern that can lead to limited treatment options for life-threatening human infections. Colistin has widespread use in …
Investigating the psychometric properties of the Patient Health Questionnaire for Adolescents (PHQ-A) and Center for Epidemiologic Studies - Depression Scale for Children (CES-DC) among young adolescents in South Africa
Article scientifique
Accès ouvert
Mirriam Mkhize, Claire van der Westhuizen, Katherine Sorsdahl
Depression among adolescents is a global concern, including in South Africa, emphasizing the need for reliable screening tools. While the the Patient Health Questionnaire Adolescent …