Association of IFNL4 and IFITM3 Genetic Variants with Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma
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Enas Osman, Marwa Mohamed, Rania Mohammed Abbas
OBJECTIVE: To ascertain the possible association of IFITM3 rs12252 and IFNL4 rs12979860 genetic polymorphisms with cirrhosis and HCC in chronic HCV-infected patients. METHODS: Genetic variations …
Drivers of success in Somaliland's preschools: a predictive machine learning model of leadership commitment and institutional capacity
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Jibril Abdikadir Ali, Befekadu Zeleke, Bahir Adem Abdulahi
This study develops a predictive machine learning model to identify the primary drivers of success in Somaliland's public preschools, conceptualized as institutional capacity. Early childhood …
The impact of smart mobility on household's travel behavior and residential self selection in a medium sized city in Nigeria
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Oluwayemi-Oniya Bosede Aderibigbe, Trynos Gumbo
Introduction Urban areas are widely recognized as key hubs of economic activity and cultural diversity, playing a vital role in both national and local economies. …
The role of gut microbiota in modulating immune responses to neglected tropical diseases: A new frontier in host-pathogen interactions
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Emmanuel Chuks Oranu, Martin Ifeanyi Ozoh, Jessica Afomachukwu Madueke
Neglected tropical diseases (NTDs), such as Leishmaniasis, Chagas’ disease, and trypanosomiasis affect billions of people worldwide, particularly in low-income regions, and pose significant public health …
Leveraging community pharmacies for HIV services in South Africa: Opportunities and constraints
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Angela Tembo, Andy Gray, Tsitsi Nyamuzihwa
Access to HIV services in South Africa remains challenging, despite their availability in the public healthcare sector. While the legislative framework allows for the provision …
Toward sustainable food system: the role of livestock farming in Matiyani village in the Vhembe Biosphere Reserve, South Africa
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Mukona T. Kone, Andani E. Budeli, Rerani Ramaano
This study explored the role of livestock farming in Matiyani village toward achieving a sustainable food system, in the Vhembe Biosphere Reserve, South Africa. Africa …
Prevalence and factors associated with musculoskeletal disorders among primary and secondary school teachers
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John Marwa Gikaro, George Claud Goi, Farida Hassan Taamala
Background: Musculoskeletal disorders (MSDs) are among the top conditions that affect the working population including teachers. Historically, Kilimanjaro region including Moshi municipal, has been a …
The prognostic significance of incomplete hematological recovery in pediatric patients with low/intermediate risk AML and negative MRD after induction 1
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Nessma Shahin, Mahmoud Hammad, Hanafy Hafez
Background: Pediatric acute myeloid leukemia (AML) accounts for approximately 25% of childhood hematologic malignancies. Outcomes have markedly improved, especially in low-risk and intermediate-risk patients, with …
User informed design of oral dispersible strips (ODS) to deliver pediatric antiretroviral therapy in Kenya: A mixed methods evaluation of product preferences and acceptability
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Sarah Finocchario‐Kessler, May Maloba, Catherine Wexler
BACKGROUND: Innovation to streamline the administration of pediatric antiretroviral therapy to infants and small children is urgently needed. The objective of this study was to …
Standardized protocol for laboratory rearing and breeding of the Lymnaeidae snail, Radix natalensis (Krauss, 1848)
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Agrippa Dube, Chester Kalinda, Tawanda Manyangadze
Freshwater lymnaeid snails are involved in the transmission of fascioliasis in tropical and subtropical Africa, Asia, as well as in temperate regions. This study improved …
Evaluating phone call follow-ups in Sub-Saharan Africa: A systematic review and meta-analysis
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Adesola Zadiat Musa, Folahanmi Tomiwa Akinsolu, Abideen Salako
BACKGROUND: Healthcare systems in Sub-Saharan Africa (SSA) face significant challenges, including limited resources, understaffing, and geographical barriers, which hinder effective healthcare delivery. Phone call follow-ups …
Challenges, innovations and considerations for the use of tongue swabs in Mycobacterium tuberculosis complex detection
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Anura David, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane
BACKGROUND: Sputum-based testing is most used for diagnosing pulmonary tuberculosis (TB), but non-sputum specimens such as tongue swabs (TS) offer additional approaches for detecting Mycobacterium …
Impacts of agricultural machine renting on cereal crop productivity and commercialization in West Gojjam Zone, Ethiopia
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Selam Tilahun, Berhanu Kuma, Amsalu Bedemo
Agricultural mechanization plays an essential role to increase production, productivity and commercialization of cereal crops. Despite the Ethiopian's government has made substantial efforts to increase …
Simple spectrophotometric methods for the quantitative analysis of two binary mixtures containing paracetamol as a major component
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Karin M. Guirguis, May M. Zeid, Rasha A. Shaalan
Abstract This work demonstrates simple and reliable spectrophotometric methods for the simultaneous determination of paracetamol (PAR) and meloxicam (MEL) in mixture I as well as …
Comparison of inflammatory cells, C-reactive protein, and lipid profile in atherosclerotic cardiovascular disease patients and healthy controls in Northwest Ethiopia
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Minyahl Kassye Mengstu, Getu Girmay, Kassaye Demeke Altaye
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of global mortality and disability. Inflammation is increasingly recognized as a key driver in the pathogenesis of …
Effects of chronic nicotine administration on behavioral parameters and Na⁺/K⁺-ATPase mRNA expression in the brains of male Swiss Albino mice exposed to chronic stress during adolescence
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NourAllah Ahmed, Mohamed Ahmed, A. A. Ragab
BACKGROUND: Stress during adolescence leads to the development of major stress-related diseases. The use of psychoactive substances and most psychiatric disorders have been linked to …
Importance of confirmatory test characteristics in optimizing community-based screening for tuberculosis: an epidemiological modeling analysis
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Lukas E. Brümmer, Theresa S. Ryckman, Sourya Shrestha
BACKGROUND: The costs, operational barriers, and sensitivity of available tools to confirm a TB diagnosis limit current active case-finding (ACF) efforts for tuberculosis (TB). However, …
Bioactivity and genotoxicity effects of certain compounds on Theba pisana and Monacha cartusiana land snails
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Nada M. T. Abbas, Sahar I. M. Abd El-Wahed, Hesham A. M. Ibrahim
Abstract Theba pisana and Monacha cartusiana , both land snails, are agricultural pests that have caused significant losses in many orchards and fields in various …
Co-application of gibberellin and copper sulphate reduces number of seeds as innovative technique for alleviating alternate bearing in Balady mandarin
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A. E. A. Shaban, Mohammed I. M. El-Banna, Ahmed Abdelhady Rashedy
Abstract Seeds are regarded as a source of gibberellins (GA) which promote fruit set, fruit growth and plant growth. However, trees with more-seeded fruits tend …
Association of GABRG2 gene polymorphisms with idiopathic generalized epilepsy in Egyptian children: a case–control study
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Yahya Wahba, Doaa Shahin, Abdel‐Hady El‐Gilany
PURPOSE: The GABRG2 gene polymorphisms C588T and 3145G>A could be predictive genetic markers that trigger idiopathic generalized epilepsy (IGE) or predict pharmaco-resistance to antiseizure medications …