Pathogenic cytokines in thrombotic microangiopathies: molecular insights and therapeutic targets
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Emmanuel Ifeanyi Obeagu
Thrombotic microangiopathies (TMAs) are a heterogeneous group of disorders characterized by endothelial damage, microvascular thrombosis, thrombocytopenia, and microangiopathic hemolytic anemia. While the initiating triggers may …
Dolutegravir rollout for treatment of HIV with a focus on advanced disease and tuberculosis coinfection: findings from rural KwaZulu-Natal, South Africa (2019–2023)
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Reuben Christopher Moyo, Larisse Bolton, Elphas Luchemo Okango
Abstract Background While Dolutegravir (DTG) containing antiretroviral therapy (ART) has become the preferred regimen for people living with HIV (PLHIV), the pace and equity of …
Immediate postpartum long acting reversible contraceptive uptake and associated factors at Asella Referral and Teaching Hospital, Ethiopia
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Alemtsehay Teshome, Adane Sisay, Amde Eshete
BACKGROUND: Utilizing postpartum long acting reversible contraceptive (LARC) is a key tactic for reducing unwanted pregnancies and increasing birth spacing. The immediate postpartum period is …
LC/ESI-MS/MS phytochemical profiling and apoptotic effect of Haloxylon scoparium leaf extract on hepatocellular carcinoma
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Mosad A. Ghareeb, Boulanouar Bakchiche, Yacine Aouiffat
Haloxylon scoparium, a plant native to Moroccan Sahara, was investigated for its potential anticancer activity against hepatocellular carcinoma (HCC). The study aimed to evaluate the …
Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus
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Adel Attia M. Ahmad, El-Sayed Y. El-Naenaeey, Abeer Salem Aloufi
Background Disrupting Staphylococcus aureus S. aureus biofilms is of utmost importance in the medical field. Identifying herbal compounds, especially those comprising enzymes, with antibacterial and …
Emotional intelligence in action: theoretical models for educators to enhance learning and connection in the classroom: a conceptual review
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Mokgata Matjie
Emotional quotient (EQ) and emotional intelligence (EI) are often conflated with cognitive intelligence (CI); however, it distinctly refers to the quantifiable assessment of an individual's …
Amikacin toxicity revisited: pentoxifylline offers protection in high-risk treatment scenarios
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Nada Moustafa, Mona B. Abd El-latif, Alyaa Farid
Amikacin (AMK), a potent aminoglycoside antibiotic, is clinically valuable for severe Gram-negative infections but is limited by its nephrotoxic and hepatotoxic effects, primarily mediated through …
Theoretical investigation of the electronic structure and magnetic properties of Ru doped LiFeAs
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Manza Zityab Kasiab, Kumneger Tadele, Mesfin Asfaw Afrassa
Abstract This study performed first-principles calculations using Density Functional Theory (DFT) and DFT+ U within the Quantum-Espresso package. . The electronic structure and magnetic properties …
Participants’ experiences of potential adverse effects of an intervention to improve critical thinking about health choices: a qualitative cross-trial process evaluation in Kenya, Rwanda and Uganda
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Matt Oxman, Faith Chesire, Michael Mugisha
OBJECTIVES: To explore participants' experiences of potential adverse effects of the Informed Health Choices secondary school intervention across three trial sites and to revise a …
Youth depression in Ethiopia: a comprehensive systematic review and meta-analysis
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Samuel Derbie Habtegiorgis, Animut Takele Telayneh, Lake Kumlachew
Abstract Background Mental health is the state of well-being that manages our emotions, psychological stress, social well-being and it is essential at all stages of …
Transactional sex, HIV, and STIs among men who have sex with men in Ghana: an MSM bio-behavioral study
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Chris Guure, Irene Animah Acheampong, Marian Abedua Harrision
BACKGROUND: Men who have sex with men (MSM) in Ghana continue to face a disproportionately high HIV burden, with an estimated prevalence of 18.1% far …
Pathways and delays in the diagnosis of autism spectrum disorder in Kenya: a cross-sectional study from tertiary hospitals in Nairobi
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Muthoni Muthiga, Anne Mbwayo, Rachel Kang’ethe
BACKGROUND: Autism Spectrum Disorder (ASD) contributes significantly to the disease burden among children and adolescents. Early diagnosis and intervention significantly improve outcomes; however, in Africa, …
Knowledge, attitude and readiness toward telehealth among nursing staff: a cross-sectional study
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Reda Hassan Hussien, Gellan K. Ahmed, Salah Omar Abdullah
BACKGROUND: Telehealth has emerged as a promising solution for improving global healthcare delivery by leveraging telecommunications and information technology in remote nursing practice. OBJECTIVES: This …
Purification and biochemical characterization of l-glutaminase from Aspergillus oryzae with potential biotechnological applications in synthesis of l-theanine and as antitumor agent
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Hamed M. El-Shora, Sally M. Metwally, Nahla T. Elazab
Fungal glutaminase is of great importance in different industries fields. Thus, searching for a significantly catalytic L-glutaminase (Glut) with appraising its biochemical properties and biotechnological …
Exploring the effect of femtosecond laser surface treatment on the bond strength of zirconia to metal brackets: an in vitro study
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Lobna Shalaby, Hatem Saifeldin, Fatma Abdel Samad
OBJECTIVE: To investigate the effect of zirconia (Zr) surface treatment with different femtosecond laser (FS) wavelengths on the shear bond strength (SBS) of metal brackets …
Preferences for tongue swab-based versus sputum-based testing in the context of TB care: a best-worst scaling exercise in Vietnam and Zambia
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María del Mar Castro, Hien Le, Seke Muzazu
BACKGROUND: The development of non-sputum-based tests is an urgent priority to increase access to tuberculosis (TB) diagnostic testing. Understanding preferences of people undergoing testing is …
Cross-cultural adaptation and psychometric evaluation of the Engaged Teachers Scale among Arabic-speaking physical education teachers
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Samia Boukari, Noomen Guelmami, Nasr Chalghaf
Background Teacher engagement is a positive psychological state characterized by vigor, dedication, and absorption in professional activities, representing the opposite of burnout. While research has …
Novel Soliton and Periodic Wave Solutions of the (3+1)-Dimensional Shallow Water Wave Equation with Bifurcation Analysis
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Wafy M. Hasan, Hamdy M. Ahmed, Ahmed M. Ahmed
This study derives novel exact traveling wave solutions for the [Formula: see text]dimensional shallow water wave equation-a pivotal model in coastal hydrodynamics for tsunami prediction …
Reimagining education in the coming decade: what AI reveals about what really matters
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Samar Ahmed
My central argument is that higher education's future lies not in defending what AI does better, but in cultivating what AI cannot replicate: epistemic judgment, …
Mapping of shore area wetlands in Lake Tana Biosphere Reserve, Northwest Ethiopia using Sentinel-1A SAR and multi-source data
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Yirga Kebede Wondim, Ayalew Wondie Melese, Workiyie Worie Assefa
Shore area wetlands (lacustrine fringe) play a critical role as ecotones that support biodiversity, provide habitats for spawning and refuge, and exhibit high levels of …