Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase
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Reem M. Elsapagh, Eman O. Osman, Ahmed M. Hafez
An efficient, reliable, and cost-effective approach was applied for the electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives. The compounds were prepared in high yields and …
Impact of titanium nanoparticles on germination and early growth of faba bean (Vicia faba L.)
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Somaia Youssif Abdelmagid, Fatma Abd El Lateef Gharib, Eman Zakaria Ahmed
Abstract This study explores the potential of biosynthesized titanium dioxide nanoparticles (TiO2NPs), capped with phytochemicals from Zygophyllum simplex extract, in enhancing seed germination and related …
Multilocus identification and genetic enhancement of Trichoderma spp. for entomopathogenic activity against Spodoptera littoralis
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Nehal Atta, Abdelmegid Ibrahim Fahmi, Khalid Abdel‐Lateif
BACKGROUND: The Egyptian cotton leafworm (Spodoptera littoralis) is a highly destructive, pesticide-resistant pest affecting over 80 economically important crops across the Mediterranean and African regions. …
A policy brief on improving reproductive and maternity services utilisation among women of reproductive age in Nigeria
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Obasanjo Afolabi Bolarinwa, Rebecca Tadokera, Ritika Tiwari
Nigeria continues to struggle with high maternal and child mortality despite its large economy. Reproductive and maternity services are underutilised, contributing to poor maternal and …
Reducing pesticide risks through social and behavior change communication: a case study of the Ukulima True campaign in Kenya
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Maureen Wairimu Njenga, Monica K. Kansiime, Tamsin Davis
Introduction Although pesticides play a critical role in enhancing crop productivity, their improper use poses serious threats to health and the environment. This study assessed …
Nutraceutical potential of moroccan Juglans regia: phytochemical profiling and multi-modal evaluation of bioactivities
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Aziz Drioiche, Omkulthom Mohamed Al Kamaly, Soukayna Baammi
This study explores the therapeutic potential of J. regia from Morocco through an in-depth phytochemical analysis and biological evaluations using in vitro, in vivo, and …
One health approach unravels worrying antimicrobial resistance patterns: A cross-sectional study in Kisii, Kenya
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Briton M. Kavulavu, Eric O. Omwenga, Oscar A. Nyangiri
BACKGROUND: Antimicrobial resistance (AMR) is a major public health challenge, particularly in Sub-Saharan Africa, where diagnostic and surveillance capacities are limited. Enterobacterales significantly contribute to …
Stocking African catfish in Lake Victoria provides effective biocontrol of snail vectors of Schistosoma mansoni
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Roland Proud, Fiona Allan, Andrew Whiston
In areas of high infection prevalence, effective control of schistosomiasis - one of the most important Neglected Tropical Diseases - requires supplementing medical treatment with …
Associations between maternal capabilities for care and nurturing care behaviours among mother-child dyads in Malawi and South Africa
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Taryn J. Smith, Emmie Mbale, Michal R. Zieff
Adequate nurturing care behaviours, including feeding practices, health-seeking and psychosocial stimulation, are crucial for the optimal health, growth and development of young children. However, several …
Opportunistic use of artificial intelligence with X-ray imaging for diagnosis of HIV status in tuberculosis patients in Uganda and Tanzania
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Dmitry Cherezov, Tanmoy Dam, Irene Najjingo
Combining market surveys and participative approaches to map small ruminant mobility in three selected states in northern Nigeria
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Sandra I. Ijoma, Asma Mesdour, Muhammad-Bashir Bolajoko
In Nigeria, a huge gap in knowledge on livestock mobility and its role on transboundary disease spread exists. As animals move, so do diseases. Therefore, …
Health risks and contamination degrees associated with heavy metals in three coastal fish from the Red Sea
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Mahmoud Mahrous M. Abbas, Yasmine Mohamed EKraim, Abdullah S. Alnasser
This study focuses on the levels of heavy metals (HMCs) in the commonly consumed marine fish from the Aqaba Gulf, Red Sea, Egypt. It evaluates …
Genomic and clinical epidemiology of SARS-CoV-2 in coastal Kenya: insights into variant circulation, reinfection, and multiple lineage importations during a post-pandemic wave
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Arnold W. Lambisia, Esther Nyadzua Katama, Edidah Moraa
Abstract Background Between November 2023 and March 2024, coastal Kenya experienced another wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections detected through our …
Effect of virtual reality on perioperative anxiety, stress and pain in total hip arthroplasty: a randomized controlled trial
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Saad Ahmed Moharam, Mohammed Said ElSharkawy, Ahmed Elkashef
BACKGROUND: Virtual reality (VR) has shown promise as a nonpharmacological alternative to pharmaceutical pain relievers and anxiety medications in clinical trials by decreasing pain and …
Exploring the impact of smart learning technologies on student engagement, e-trust, and satisfaction in higher education institutions: the moderating role of ethical perceptions
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Ichrak Riahi, Wafa Battikh, Hanen Khanchel
Abstract The increasing adoption of digital technologies necessitates understanding factors impacting student engagement, trust, and satisfaction with smart learning technology (SLT) in Tunisian Higher Education …
A qualitative study of patient choices between herbal and hospital care for infectious diseases in Somalia
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Mohamed Jayte, Abdifitah Abdullahi Mohamed, Abishir Mohamud Hersi
Somalia's healthcare system is marked by a reliance on traditional medicine and under-resourced modern facilities. This study explores how communities navigate treatment choices for infectious …
Predictors of drug-resistant TB outcomes: Body mass index, HIV, and comorbidities
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Ntandazo Dlatu, Lindiwe Faye, Ncomeka Sineke
BACKGROUND: The success rates for treating drug-resistant tuberculosis (DR-TB) in programmatic settings have been unsatisfactory. By identifying the factors that predict treatment outcomes, we can …
Dual GSK3β/SIRT1 modulators for Alzheimer’s: mechanisms, drug discovery and future perspectives
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Afeez I. Kareem, Erika Kapp, Jacques Joubert
Alzheimer’s disease (AD) remains without effective disease-modifying therapies, in part due to the limited efficacy of single-target approaches. Dual modulation of glycogen synthase kinase-3β (GSK3β), …
Improving heat resilience in fattening rabbits: nutritional strategies for mitigation via regulating blood physiology, inflammation and antioxidant pathways
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Hadeel K. Khaleel, Sameh A. Abdelnour, Raha Osailan
Introduction Global heat waves increasingly threaten food security, by reducing food supplies and negatively impacting livestock health. This research investigates nutritional interventions aimed at improving …
The Ethiopian Surgical Outcome Study (Ethio-SOS): a 7-day multicentre national prospective observational cohort study
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Atalel Fentahun Awedew, Fitsum Kifle, Katherine R. Iverson
INTRODUCTION: Safe surgical care is a cost-effective intervention for addressing a wide range of conditions, yet postoperative complications remain a leading global cause of disability, …