Time to treatment failure and its predictors among children receiving first-line antiretroviral therapy in Tigray Region public general hospitals, North Ethiopia, 2024: Retrospective cohort study
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Ainom Shimondi Shishay, Berhe Beyene Gebrezgiabher, Yohannes Kinfe Gebreyohannes
BACKGROUND: Pediatric human immunodeficiency virus (HIV) remains a significant public health challenge, with an estimated 1.5 million children living with HIV globally. In addition, first-line …
Determinants of Wayfinding and Information Access for Migrants in Tunisia: A Study During the COVID-19 Pandemic
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Aymen Ghédira
This study examines the determinants of wayfinding and information access difficulties experienced by Sub-Saharan African migrants in Tunisia during the COVID-19 pandemic. Using survey data …
Role of NOX2 in the regulation of inflammatory and apoptotic pathways in congolese patients with type 2 diabetes in Brazzaville
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Feddercen Kelly Helga Mayassi, Charley Loumade Elenga-Bongo, Ghislain Loubano-Voumbi
Background: Type 2 diabetes (T2D) represents a major global health challenge, characterized by insulin resistance, β-cell dysfunction and chronic inflammation closely linked to reactive oxygen …
Targeted metabolomics to quantitatively profile changes in amino acids and phenolics at every step of amahewu production from two Zea Mays L. maize types (white and yellow)
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Sebotse Dolly Kgoale, Abdullahi Adekilekun Jimoh, Fidele Tugizimana
Most existing research on amahewu has primarily examined the microbial and physicochemical properties of beverages, leaving the overall metabolite profile insufficiently characterized. Metabolomic analysis enables …
Comparative analysis of Buruli ulcer in Ghana and Côte d’Ivoire: A cross-sectional study
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Elizabeth Gyamfi, Magdalene Dogbe, Mabel Sarpong-Duah
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical skin disease highly endemic in West Africa and Australia. The molecular diversity of M. …
Ubuntu Leadership in Organisational Contexts: A Review of the Literature and Suggestions for Further Research
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Kerryn Powell, Anton Grobler
Purpose: This study investigates how Ubuntu leadership has been portrayed within organisational contexts using a systematic literature review methodology to synthesise the literature in a …
Stressors in sports coaching: a survey of South African sports coaches
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Lesego Phetlhe, Heather Morris-Eyton, Alliance Kubayi
Sports coaching is a highly stressful profession due to the variety of responsibilities and expectations placed on coaches. The purpose of this study was to …
Synergistic effects of integrating date palm biochar, compost, and compost tea: an agroecological approach to enhancing tomato growth and soil fertility
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Mariyem Rehali, Sahar Bouchboua, Naïma El Ghachtouli
This study investigated the synergistic effects of integrating date palm biochar, compost, and compost tea on soil fertility, microbial activity, and tomato ( Solanum lycopersicum …
Enhanced multi-class object detector for bone fracture diagnosis with prescription recommendation
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Daudi Mashauri Migayo, Shubi Kaijage, Stephen Swetala
Bone fractures are among the most prominent injuries in the modern world that affect all ages and races. Traditional treatment involves radiographic imaging that relies …
A call for a paradigm shift to community-embedded, home-based primary preventive oral health care in Africa
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Moréniké Oluwátóyìn Foláyan, Ahmed Bhayat, Maha El Tantawi
Oral diseases constitute a global public health crisis, affecting nearly 3.5 billion people worldwide [1]. They cause pain, disability, and economic loss, with their highest …
Distribution, conservation, and indigenous knowledge of finger millet germplasm in different agroecologies in Uganda
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Scovia Adikini, Ronald Kakeeto, Steven Senabulya
Introduction Crop improvement is crucial in addressing food and nutritional security, as it requires a wide range of genetic diversity to serve as germplasm during …
Effectiveness of cognitive behavioral therapy for hypertension-related psychological distress: a two-phase randomized controlled trial in a Nigerian tertiary hospital
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Addah Temple Tamuno-Opubo, Wandile Fundo Tsabedze, Curwyn Mapaling
Background Hypertension is a major contributor to cardiovascular morbidity globally and is frequently accompanied by psychological distress, including anxiety and depression. Evidence on the efficacy …
Prevalence and associated factors of human haemorrhagic fevers in Senegal: a comprehensive analysis of Hantaan, Crimean-Congo haemorrhagic fever and Rift Valley fever
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Maryam Diarra, Safiétou Sankhe, Mamadou Aliou Barry
Introduction: Viral haemorrhagic fevers such as Rift Valley fever, Crimean-Congo haemorrhagic fever, and hantavirus disease continue to threaten public health in Africa. This study assessed …
Eczema: etiology, subtypes, therapeutic approaches and socioeconomic impact
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Marizé Cuyler, Danielle Twilley, Namrita Lall
Eczema is an inflammatory skin condition that affects individuals of all ages worldwide. Patients may develop various forms of eczema, including atopic dermatitis, contact dermatitis, …
Natural polymers in diabetes management: formulation prospects of Hibiscus rosa-sinensis mucilage for metformin sustained release
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Nsibambi Ronald Kizza, Sarad Pawar Naik Bukke, Ungo-Kore Hussain Yahaya
Diabetes mellitus (DM) is a long-term metabolic disorder distinguished by hyperglycemia with the limitation of severe complications unless treated effectively. Metformin is the first-line agent …
Evaluating the dynamics of carbon accumulation in extensive argan orchard ecosystems in arid regions
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Assma Oumasst, Fatima Ezzahra Tiouidji, Naima Chabbi
Abstract Background Extensively cultivated argan orchards in Argan Biosphere Reserve in Morocco, aged 2–10 years, were assessed to quantify ecosystem components (above-ground argan biomass, leaf …
Effect of drying methods, pretreatment and storage conditions on nutritional quality and consumer acceptability of cocoyam leaves (Xanthosoma sagittifolium)
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Gloria Ladjeh Essilfie, Matilda A. D. Afful, Roslyne N. N. Baddoo
Cocoyam leaves ( Xanthosoma sagittifolium ) are an underutilized, nutrient-rich traditional leafy vegetable commonly consumed in Ghana. However, their high moisture content leads to rapid …
Mandatory food fortification in the eastern Mediterranean region results in reduced prevalence of neural tube defects
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Sylvia Roozen, Quentin Johnson, Eman T. Ibrahim
Introduction: Neural Tube Defects (NTDs) are preventable congenital malformations affecting the brain and spinal cord that occur very early in pregnancy, often before gestation is …
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review
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Claudia Ntsapi, Morné Weyers, Rosa M. Chinheya
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of toxic protein aggregates in the brain, leading to brain cell death and cognitive …
Social determinants of health associated with the clinicopathological presentation of patients with prostate cancer in Kenya
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Charles G. Waihenya, SM Thumbi, Daniel Ojuka
Introduction In Kenya prostate cancer (Ca) is the leading cause of cancer related mortality among men. There is lack of data on the social determinants …