Syndromic cholera diagnosis masks diverse causes of diarrhoeal disease in Burundi revealed by portable metagenomics
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Emilie Egholm Bruun Jensen, Néhémie Nzoyikorera, Mirena Ivanova
Abstract Background Cholera outbreaks remain a major public-health challenge in sub-Saharan Africa, where diagnostic capacity is limited and clinical case definitions are non-specific and reply …
Remote engineering of particle-like topologies to visualise entanglement dynamics
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Fazilah Nothlawala, Bereneice Sephton, Pedro Ornelas
Skyrmions are a particle-like topology with a quantized skyrmion number, realized across condensed matter and photonic platforms alike. In quantum photonics, they constitute an emerging …
Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population
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Eddy Kinganda Lusamaki, Ana M. Ortega-Villa, Daouda Camara
Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants …
Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments
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Marina M. Watowich, Rachel M. Petersen, Layla Brassington
The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in …
Talaromyces marinus (Eurotiales, Trichocomaceae): a new marine fungus from the Red Sea, Egypt, with distinguished enzymatic capabilities
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Ahmed Elbadry Abdel-Aziz, Enas Mahmoud Amer, Mahmoud S. Bakhit
BACKGROUND: Talaromyces C. R. Benj., is a large and taxonomically important genus within Ascomycota, established to accommodate the teleomorphs of certain Penicillium Link, species and …
AfCFTA Expectations and Border-Level Implementation Challenges in Southern Africa
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Martha Tchikwambi, Karikari Amoa-Gyarteng, Marius Frederick Johannes
Abstract This paper examines how individuals at a major Southern African border point perceive the African Continental Free Trade Area (AfCFTA). It draws on 23 …
Autologous bone grafts versus alloplastic implants for orbital floor reconstruction: a systematic review and meta-analysis
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Mohammed Ehmidat, Ahmed Samy Gad, Ahmad Omar Saleh
Development of Penalized Estimation for Conway-Maxwell-Poisson Regression under Multicollinearity and High Dimensionality
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Ibrahim M. Taha, Mohamed R. Abonazel, Amany Mousa
Modern count data applications are increasingly characterized by dispersion, high dimensionality, and strong predictor dependence, conditions under which maximum likelihood estimation for Conway--Maxwell--Poisson (COM-Poisson) regression …
Health system readiness for immediate Kangaroo Mother Care (iKMC) among network of care facilities in the Sidama region, Ethiopia: a mixed-method study
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Abiy Seifu Estifanos, Hailemariam Negash, Setisemhal Getachew
Introduction: Despite Ethiopia's remarkable progress in reducing deaths among children under five, neonatal mortality remains high. The provision of immediate Kangaroo Mother Care (iKMC) for …
Trends in advanced HIV disease, treatment interruption, and viraemia in KwaZulu-Natal, South Africa
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Sanele S. Mbeje, Lilishia Gounder, Johan van der Molen
Advanced HIV disease (AHD), treatment interruption and viraemia remain key challenges to effectiveness of HIV programmes in South Africa. Understanding the trends of these measures …
Facilitators and barriers to the implementation of a caregiver-led training programme for caregivers of children with cerebral palsy in rural Malawi
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Takondwa Connis Bakuwa, Gillian Saloojee, Wiedaad Slemming
BACKGROUND: The implementation of caregiver-led training programmes for complex childhood-onset conditions like cerebral palsy is challenging as multiple factors influence outcomes, particularly in rural, resource-constrained …
VRWKV-Editor: reducing quadratic complexity in transformer-based video editing
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Abdelilah Aitrouga, Youssef Hmamouche, Amal El Fallah Seghrouchni
EPOBPA: Extensible Parallelizable Optimized Buddy Prima Algorithm
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Mona Farouk, Mohamed Abdel Gawwad
Abstract Data is the growing new natural resource; in today’s world many organizations have a vast amount of data and they need a method to …
Asymptotic analysis of boundary layers for Stokes systems in periodic homogenization
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Moustapha Agne
We investigate the asymptotics of boundary layers in periodic homogenization. The analysis is focused on a Stokes system with periodic coefficients and periodic Dirichlet data …
Регуляризация информационных регистров вакуума в доктрине R-МИР: безнулевая фильтрация энтропийного шума и детерминированный рантайм ядра CORE
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Антон Шалыга
В работе представлен концептуальный и математический базис доктрины R-МИР, переводящей описание физической реальности со статических дифференциальных уравнений непрерывного пространства-времени на язык распределенной исполняемой подложки. Обоснована …
Navigating aid and climate pressures to achieve food security in Somalia
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Amir Mohamud Mohamed, Abdulfatah Mohamed Abdullahi
Abstract Food security in Somalia remains a critical concern due to prolonged conflict, climate shocks, and economic instability. Recurrent droughts and floods have disrupted agricultural …
Disclosure of HIV status to children on antiretroviral therapy: Perspectives and experiences of healthcare providers in the Masaka region, Uganda
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Robert Kairania, Washington Onyango‐Ouma, Tom G. Ondicho
BACKGROUND: This study explored healthcare providers' perspectives and experiences regarding HIV status disclosure to children receiving antiretroviral therapy (ART) in the Masaka region of Uganda. …
Adaptation and pilot implementation of the WHO guideline on digital intervention to strengthen mental health systems in Lagos state, Nigeria
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Abiodun O. Adewuya, Jibril Abdulmalik, Seye Abimbola
BACKGROUND: The uptake and implementation of cost-effective interventions and programs for mental health problems are often threatened by weakened health systems (HS) in low- and …
Advanced hybrid-stabilized cinacalcet nanocrystals for enhanced oral bioavailability: formulation and integrated in vitro/in vivo evaluations
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Rawan Gamal Eldin, Salma M. Mosleh, Osama Saher
Introduction Cinacalcet (CINA), a Biopharmaceutics Classification System (BCS) Class IV drug, exhibits limited oral bioavailability due to poor aqueous solubility and low intestinal permeability. We …
Raising the bar: translating global guidelines to achieve local policy on cholera elimination in Zambia—a qualitative case study
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Chanda Mwamba, Tikulirekuti Banda, Mazyanga Mazaba
BACKGROUND: The global roadmap to eliminating cholera by 2030 relies on early detection and response, vaccination in hotspots and effective partnerships. In sub-Saharan Africa, where …