Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility
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Ahmed A.A.M.M. Alkhatip, Usama Raza, Ehab Farag
Introduction: Short-acting ketamine-related scaffold design remains an important medicinal-chemistry problem, but computational studies require conservative interpretation until receptor, enzymatic, and pharmacokinetic validation is available. Methods: …
Reducing immunization inequities among zero-dose and under-vaccinated children through catch-up vaccination in Burkina Faso: findings from a mixed-method evaluation of the Big Catch-Up initiative, 2023–2025
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Amidou ZONGO, Hadiatou Diallo, Crepin Hilaire DADJO
Whole-genome sequencing reveals divergent and shared selection signatures of heat stress adaptation in indigenous Ethiopian zebu cattle from dry-hot and humid-hot environments
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Endashaw Terefe, Gurja Belay, Abdulfatai Tijjani
African zebu cattle (Bos indicus) exhibit remarkable adaptations to extreme thermal conditions, yet the genomic basis of this resilience remains incompletely characterized. Ethiopia provides a …
From Desk Review to Field Verification and the Tax Audit Modality Revenue Paradox in Southwest Nigeria
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Grace Wale-Ajayi, Gideon Akinleye, Tajudeen Ajayi
This study examines why desk audits can be perceived as operationally useful while showing little independent association with revenue generation, and whether field verification supplies …
Brain metastasis secondary to primary vaginal clear cell adenocarcinoma not associated with diethylstilbestrol: a case report and a review of the literature
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Esther Anyimadu Buckson, Obi Emereole, John Richard Ouma
Background: exposure to diethylstilbestrol (DES). Patients with non-DES-related PCCAV are even scarcer and usually have a worse prognosis. PCCAV has been reported to metastasize to …
The community drug distributor passport: a case study of training and recognition in Chad
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Sohaibou Diane, Adoum Mahamat Oumar, Barka Kali
Introduction: Community health workers (CHWs), particularly volunteer community drug distributors (CDDs), play essential roles in advancing universal health coverage (UHC) and neglected tropical disease (NTD) …
Reimagining inclusive mathematics education in Ghana through ethnomathematics
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Bright Asare
This study investigates the integration of ethnomathematics into Ghana's mathematics curriculum as a pathway to achieving inclusive and culturally responsive education. Despite multiple post-independence curriculum …
Using urban nitrate-rich groundwater for peri-urban irrigation in Dakar, Senegal: an evaluation of water quality concerns
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Mandiaye Diene, Abdoulaye Pouye, Viviana Ré
Contamination of urban groundwater from faecal effluent in sewered and unsewered areas is a widespread constraint to its use for water-supply provision. Here, we present …
Exploring the factors associated with diabetes and hypertension complications among refugees living in Egypt
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Noura Seada, Sungsoo Chun
Introduction Non-communicable diseases (NCDs) account for 74% of global deaths, with high global prevalence of diabetes and hypertension. Egypt hosts over 1 million refugees and …
The limits of awareness campaigns: persistent age-disparate relationships in KwaZulu-Natal more than a decade after the 2012 sugar daddies destroy lives campaign
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Sbonelo Chamane, Lehlogonolo Makola, Sean Jooste
In 2012, the KwaZulu-Natal (KZN) Department of Health launched a comprehensive public health campaign "Sugar Daddies Destroy Lives" discouraging adolescent girls and young women from …
Trait-Dependent and Site-Specific Effects of Foliar IAA and Kinetin on Two Chickpea Varieties Grown Under Contrasting Conditions
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Z. Kebaili, Abdelouahab Yahia, Ayache Boultif
Abstract Chickpea (Cicer arietinum L.) yield in Algeria still falls short of domestic demand, and low-cost agronomic tools such as plant growth regulators are one …
Stakeholders’ perceptions of the teaching–learning and assessment quality in Ethiopian public universities
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Samuel Assefa Zinabu, Adamu Assefa Mihirka, Hailu Wubshet
Ensuring the quality of teaching–learning and assessment processes is a fundamental responsibility of higher education institutions and a critical determinant of institutional effectiveness and graduate …
A 10-year Cancer Registry Analysis on Demographic, Clinicopathological, and Treatment Characteristics for Head and Neck Cancer Patients in Zambia
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Chrispinus Hakimu Mumena, Jenny Öhman, Bengt Hasséus
Effects of Acacia cyanophylla -condensed tannin supply on growth performance, carcass characteristics and meat quality of fat-tailed Barbarine lambs studied under grazing conditions or in a feedlot
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Yathreb Yagoubi, N. Atti, Samir Smeti
The aim of this study is to evaluate the effects of dietary supplementation with acacia foliage, a tannin source, and feeding systems on Barbarine lambs' …
Mechanistic Pathways of Biochemical and Toxicological Responses to Waste Tyre Combustion Emissions: A Systematic Review
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Stephen Kusi, Christopher Larbie, Benjamin Obukowho Emikpe
A Sociolinguistics Survey of Language Diversity, Attitude, and Use in Bo District, Southern Sierra Leone.
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John E. Stevens, Abu Bakarr Sheriff
Sierra Leone has English as a heritage of British Colonial rule (1808-1961) that continues to serve as her only official language and language of the …
Antimicrobial resistance patterns in pregnancy and their relationship to early onset Neonatal infection in tertiary level hospitals in Rwanda
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Jean Pierre Bucyebucye, Patrick G. Bagambe, Kenneth Ruzindana
Phosphate removal by spent low temperature shift catalyst through process optimization and mechanistic study
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Fatma E. A. Hashem, Abeer M. Shoaib, Walaa A. E. Omar
Abstract Natural water bodies become eutrophic due to phosphate pollution from industrial and agricultural sectors. This research addresses waste disposal and water pollution at the …
Personal sense of coherence and posttraumatic stress symptoms among internally displaced women exposed to the Anglophone Crisis in Cameroon
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Edwige Emilie Kouamen Tatto Mouandjo, Anne Wandjiru Mbwayo, Anne Muthoni Mathai
Women and girls affected by armed conflict and forced displacement are exposed to a high burden of potentially traumatic events, gendered insecurity, disrupted social networks, …
Investigating connections between economic diversification, climate change, renewable energy and agriculture in MENA countries: new findings from the panel CS-ARDSL model
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Ghassen El Montasser, Hichem Saidi, Simplice A. Asongu
Introduction Agriculture remains a vital sector for economic development and food security in MENA countries, yet it faces increasing challenges from climate change. At the …