440 publication(s) trouvée(s)
Article scientifique
Comparison Between Breath-Hold and the Inspiratory Phase of Free Breathing in Left Breast Cancer Radiotherapy: Target Volume Coverage and Organ Sparing
BACKGROUND: Cardiac mortality and coronary events associated with left breast radiotherapy are correlated with the mean radiation dose to the …
Article scientifique
The Synergistic and Anticancer Potential of Withania Somnifera (Ashwagandha) Ethanol Extract as an Adjuvant with Doxorubicin in MCF7 Breast Cancer Cell Line
BACKGROUND: Recent approaches in breast cancer treatment involve exploring natural extracts either as substitutes for traditional chemotherapeutic agents or as …
Article scientifique
The Genetic Influence of Programmed Death Ligand-1 (PD-L1) Single Nucleotide Polymorphisms on the Incidence of B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians
OBJECTIVE: This study was conducted to investigate the relationship between rs4143815 (C>G) and rs2890658 (A>C) of the PD-L1 (Programmed Death-Ligand …
Article scientifique
Expression Analysis of Oxidative Stress Markers 8-hydroxydeoxyguanosine and Protein Carbonyl in Breast Cancer and Their associations with Certain Immunological and Tumor Markers
OBJECTIVE: Breast cancer (BC) is a heterogeneous disease, recognized as a major public health problem worldwide, with several risk factors …
Article scientifique
In vitro Evaluation of Zinc Oxide-Metformin Folic Acid Nanocomposite as a Targeted Drug Delivery System for Cancer Therapy
BACKGROUND: Cancer has become the second cause of death worldwide after cardiovascular diseases. Thus, the development of efficient therapeutic approaches …
Article scientifique
Detection of H-Pylori in the Explanted Liver Tissue and the Enlarged Perihepatic Lymph Nodes of Cirrhotic Patients with Decompensated End-Stage Liver Disease Recruited for Liver Transplantation
BACKGROUND: Helicobacter pylori bacteria colonize the gastric mucosa and contribute to the occurrence and development of gastrointestinal diseases. According to …
Article scientifique
Breaking Barriers in Cancer Screening: Understanding Participant Dropout in Breast and Cervical Programs in Morocco
OBJECTIVE: This study aimed to investigate loss to follow-up (LFU) rates within breast and cervical cancer screening programs in Kenitra-Morocco, …
Article scientifique
Immunohistochemical Expression of PD-L1 and CTLA-4 in Triple Negative Breast Cancer and Their Prognostic Associations
OBJECTIVE: Programmed Death-Ligand 1 (PD-L1) and Cytotoxic T Lymphocyte -Associated Antigen-4 (CTLA-4) are presently considered as prognostic markers and therapeutic …
Article scientifique
Potential Role of the Tie2/ Angiopoietin System in Hepatitis C Virus- Induced Hepatocellular Carcinoma
BACKGROUND: The Tie2/Ang pathway was found to be involved in forming tumor blood vessels in various tumors. The goal of …
Article scientifique
Health Related Quality of Life and Religiosity of Women with Cervical Cancer in the Souss-Massa Region, Morocco: A Cross-Sectional Study
BACKGROUND: Cervical cancer is a highly prevalent cancer among women, especially in low- and middle-income countries. This disease affects women …
Article scientifique
Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry
BACKGROUND: Cancer is a major cause of morbidity and mortality in Tunisia. The objectives of our study were to estimate …
Article scientifique
Prospective Validation of a One-Step RT-qPCR-based Test for Quantifying HER2 Gene Expression in Breast Cancer
OBJECTIVE: To Validate a one-step RT-qPCR as a reliable diagnostic tool in HER-2 positive breast cancer. Further, establishing this tool …
Article scientifique
Targeted Sequencing of HER2-Positive Breast Cancer Mutations Revealed a Potential Association between PIK3CA and Trastuzumab Resistance
BACKGROUND: Different molecular subtypes, including HER2-positive, have been identified in breast cancer. The overexpression of HER2 triggers downstream signaling pathways …
Article scientifique
Identification of Molecular Subgroups of Muscle-Invasive Urothelial Bladder Cancer and Their Impact on Treatment Outcome
PURPOSE: Neoadjuvant chemotherapy (NACT) improves muscle-invasive bladder cancer (MIBC) survival. However, its efficacy is limited to a group of patients. …
Article scientifique
Anticancer Properties of Garlic and Ginger Extract in Colon Cancer Cell Line
Colon cancer typically affects older adults, though it can happen at any age. Colon cancer, also known as Caco-2, is …
Article scientifique
Significance of CD70, VEGF, and CD90 Immunohistochemically Expression in Colorectal Cancer
BACKGROUND: Colorectal cancer is the 4th most reported reason for cancer death worldwide. It is a complex and multifaceted disease …
Article scientifique
Anti-viral and Apoptotic Induction of m-TOR Inhibitor Drugs against Hepatitis C Virus Activity and Hepatocellular Carcinoma Cell Line: In vitro and in silico
OBJECTIVE: This study investigated the potential of m-TOR inhibitor drugs (sirolimus, everolimus, and tacrolimus) in combating both hepatocellular carcinoma (HCC) …
Article scientifique
Adherence to Oral Hormonal Treatment among Breast Cancer Patients in Egypt
BACKGROUND: Adjuvant endocrine therapy has been shown to improve treatment outcomes in breast cancer patients. However, not all patients can …
Article scientifique
Identification of Bioactive and Anticancer Properties of Bidens Pilosa in-vitro Evidence
OBJECTIVES: Bidens pilosa and Trianthema portulacastrum are noteworthy weeds with a series of bioactive flavonoid constituents, hence, they can be …
Article scientifique
In Vivo Detection of Multidrug-Resistance Related Proteins in Locally Advanced Breast Cancer Using 99mTc-MIBI SPECT/CT Imaging: Correlation with Clinical Outcomes
OBJECTIVE: Neoadjuvant chemotherapy (NACT) is widely used for treating locally advanced Breast cancer (LABC). However, development of multidrug resistance (MDR) …