659 publication(s) trouvée(s)
Article scientifique
Discovery and structure–activity relationship analysis of 2-Pyridyl Thieno[3,2-d]pyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer
Abstract Mycobacterium ulcerans , the bacterium causing Buruli ulcer (BU), can potentially develop resistance to existing antibiotics (rifampicin - clarithromycin/ …
Article scientifique
Maternal and cross-stage effects of Metarhizium fungal infection on the malaria mosquito Anopheles coluzzii life-history
Abstract Background Entomopathogenic fungi of the Metarhizium genus are widely used as biocontrol agents against harmful insects. These fungi are …
Article scientifique
An oviposition pheromone, hexadecanoic acid, found on the eggs of Phlebotomus papatasi from Central Tunisia, attracts gravid females and stimulates oviposition
Abstract Phlebotomus papatasi is a vector of Leishmania major , the etiologic agent of zoonotic cutaneous leishmaniasis, a disfiguring and …
Article scientifique
Precision Through Frequency-Aware Prioritization: Introducing the Bouziane Similarity Index (BSI) for Rare Variants
Abstract Current genetic similarity metrics, including Identity-by-State (IBS) and Kinship coefficients, treat all alleles equally, ignoring allele frequency differences and …
Article scientifique
Assessing the population genetic structure and demographic history of Anopheles gambiae and An. arabiensis at island and mainland sites in Uganda: Implications for testing novel malaria vector control approaches
Abstract Despite substantial investments in malaria control, the disease remains a major burden in sub-Saharan Africa, particularly Uganda. Novel tools …
Article scientifique
Lightning-caused disturbance frequency and severity varies with topography in an Afromontane forest
Abstract Lightning is an important agent of tropical tree mortality, but we know little about lightning-caused disturbances beyond one lowland …
Article scientifique
Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes
ABSTRACT The immune mechanisms induced by the Bacillus Calmette-Guérin (BCG) vaccine, and the subset of which mediate protection against tuberculosis …
Article scientifique
Transcriptomic Dichotomy in Melanoma: Proliferative Cell Cycle Shield vs. Autoimmune-like Chromatin Activation in Anti-PD-1 Response
Abstract Primary resistance to anti-PD-1 therapy in metastatic melanoma remains a clinical challenge. This study reanalyzed the GSE168204 dataset to …
Article scientifique
Molecular epidemiology of Theileria parva in Eastern Democratic Republic of Congo: Implications to the introduction of the Muguga Cocktail vaccine for East Coast Fever
Abstract East Coast Fever (ECF) is one of the most economically important tick-borne diseases of cattle in Eastern, Central, and …
Article scientifique
The influence of Temperature and Relative Humidity on the Development and Survival of Laboratory-Reared Anopheles arabiensis in Ethiopia
Abstract Malaria, a major vector-borne disease transmitted by female Anopheles mosquitoes, remains a critical public health challenge in tropical and …
Article scientifique
Enhancing Secondary School Students’ Attitudes towards Biology through Guided Inquiry-Based Lab Instructions
Abstract Attitude plays a vital role in achieving modern science education goals by enhancing students’ conceptual understanding, motivation, academic performance, …
Article scientifique
Precision Breathing: Asthma Phenotyping via Machine Learning
Abstract Asthma is a complex condition characterized by chronic airway inflammation, with varying severity, symptoms, triggers, and treatment responses. Traditional …
Article scientifique
Snapshot of Defense Systems in Multidrug Resistant Klebsiella pneumoniae
ABSTRACT Objectives The defense mechanisms in bacterial pathogens protect them from host immune systems, bacteriophage infections and stringent environmental conditions. …
Article scientifique
Genomic and Bioinformatic Insights into Enterococcus faecalis from Retail Meats in Nigeria
Abstract Background Enterococcus faecalis (E. faecalis) is a commensal and opportunistic pathogen increasingly recognized for its antimicrobial resistance (AMR) and …
Article scientifique
Identification of ESBL-producing enterobacterales from vegetable plants in a rural area of Madagascar: insights into AMR transmission at the human-animal-environment-plant interface
Summary Extended-spectrum b-lactamases (ESBL)-producing enterobacterales are considered a key indicator for antimicrobial resistance (AMR) epidemiological surveillance in animal, human and …
Article scientifique
The chemistry and morphology of Vepris wadigo (Rutaceae) a new Endangered tree of Kenyan coastal forest with the description of wadigin, a newly named alkaloid
Summary Here we describe Vepris wadigo based on new collections and observations of the informally published Diphasia sp. A of …
Article scientifique
Antimicrobial and Antioxidant Activity of Ethanolic Extracts of Charred and Uncharred Skins of Four-Toed Hedgehog, Atelerix albiventris (Erinaceidae) used in Traditional Management of Boils in Ghana
Abstract Aim The charred dry skin of the Four-toed Hedgehog ( Atelerix albiventris ) is used as traditional medicine to …
Article scientifique
Differential association of SARS-CoV-2 IgG responses with anti-OC43 IgG in a Senegalese cohort
Abstract Numerous studies elucidated the kinetics of the humoral immune response post-SARS-CoV-2 infection. However, in sub-Saharan Africa, the evolution of …
Article scientifique
Evaluation of nanopore sequencing for increasing accessibility of eDNA studies in biodiverse countries
Abstract Biodiversity loss is a global challenge of the 21st century. Environmental DNA (eDNA)-based metabarcoding offers a cost- and time-efficient …
Article scientifique
Genomic Insights into the Diversity, Antimicrobial Resistance, and Zoonotic Potential of Campylobacter fetus Across Diverse Hosts and Geographies
Abstract Background Campylobacter fetus causes reproductive diseases in livestock and zoonotic infections in humans, especially in immunocompromised individuals. Despite its …