659 publication(s) trouvée(s)
Article scientifique
A natural history of AMR in Klebsiella pneumoniae : Global diversity, predictors, and predictions of evolutionary pathways
Abstract Antimicrobial resistance (AMR) is a substantial and growing global health burden. Understanding, and predicting, its evolution in specific pathogens …
Article scientifique
High-Resolution 16S rRNA and Metagenomics Reveal Taxonomic, Functional Restructuring and Pathogen Persistence in Egyptian Treated Wastewater
Abstract Wastewater treatment plants (WWTPs) are pivotal for environmental protection and public health, yet the ecological dynamics of microbial communities …
Article scientifique
Artificial Intelligence for Genomics and Bioinformatics: Is Africa Lagging Behind?
Summary Africa’s diverse pathogen and human genetics present significant opportunities for genomic medicine research using artificial intelligence (AI). We surveyed …
Article scientifique
Antibacterial potential of selected extracts and silver nanoparticles from bacterial endophyte harboured by Cola acuminata and Cola nitida (Sterculiaceae) roots
Abstract Introduction Antimicrobial resistance (AMR) is currently a global health issue in most countries. Harnessing endophytic at present. Antibiotic resistance …
Article scientifique
Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications
Abstract Systemic lupus erythematosus (SLE) and melanoma both involve dysregulated immune pathways, yet their molecular convergence remains poorly understood. We …
Article scientifique
Optimization of Substrate and Fermentation Conditions for Mycoprotein Production from Pleurotus ostreatus (Oyster Mushroom) Cultivated on Sugarcane Straw and Cassava Peels in Okitipupa, Nigeria
Abstract Mycoprotein, a sustainable protein source, can be produced from various substrates using fungi like Pleurotus ostreatus . This study …
Article scientifique
Molecular mechanisms of anti-diabetes effects of Mormodica charantia L. Ethanolic leaf extract on type 2 diabetes in strains of Drosophila melanogaster meigen, 1838
ABSTRACT Type 2 diabetes (T2D) is a chronic metabolic disorder characterized by reduced insulin sensitivity and poor glucose utilization. This …
Article scientifique
Phenological characterization of Mozambican native caprine breeds assessed through morpho-biometric traits and zoometric indices
Abstract This study aimed to characterize the morpho-structural traits of indigenous goats reared at the Chobela Research Station in the …
Article scientifique
Baobab isotope records and rainfall forcing in southwest Madagascar over the last 700 years
ABSTRACT Highly resolved climate records for Madagascar are scarce but are essential for understanding of rainfall drivers over time and …
Article scientifique
Phytochemical Analysis And Pharmacological Effects Of Gongronema Latifolium Extracts On Tamoxifen-Induced Toxicity In Wistar Rats
Abstract Background Tamoxifen, a widely used anti-estrogen medication, is known to induce oxidative stress, hepatic toxicity, and hematological disorders. Gongronem …
Article scientifique
Identification of mycobacterial efflux pump inhibiting compounds from Berberis holstii Engl. and determination of their mechanism of action
Mycobacterium tuberculosis (Mtb), the causative agent for tuberculosis (TB), is the leading infectious killer of humankind. In 2023, an estimated …
Article scientifique
Knowledge, Attitudes and Practices on Antimicrobial Resistance Among Practising Veterinary and Para-veterinary Professionals in Zambia
Abstract In this study, we aimed to assess the knowledge, attitudes, and practices (KAP) of veterinary and para-veterinary professionals concerning …
Article scientifique
Impact of Environmental Variables on the Seasonal Dynamics and Relative Abundance of Endosymbionts in Glossina Species in Northern Nigeria
Abstract This study explores how environmental factors influence the seasonal patterns and endosymbiont abundance in Glossina species across four ecological …
Article scientifique
Morphological and genetic heterogeneity in Aedes aegypti (Diptera: Culicidae) populations across diverse landscapes in West Africa
Abstract Native to sub-Saharan Africa, Aedes aegypti has spread across the globe and is now one of the most significant …
Article scientifique
Diversity of soil bacterial communities in response to fonio genotypes and pedoclimatic conditions in Benin
Abstract In sub-Saharan regions, soil fertility is a major concern for plant productivity, influenced by physical, chemical, and biological components. …
Article scientifique
Local adaptation of Gladiolus carneus to soil nutrient extremes in the Cape Floristic Region
ABSTRACT Premise Within the hyper-diverse Cape Floristic Region (CFR), divergent edaphic niches are hypothesised as an important driver of lineage …
Article scientifique
Inhibitory NK receptors regulate the γδ T cell response to malaria
ABSTRACT Gamma delta (γδ) T cells are important mediators of the immune response to childhood malaria infection. Human Vγ9 + …
Article scientifique
Endothelial Function: A Novel Marker to Evaluate the Prognosis of Heart Failure with Reduced Ejection
Abstract Background Endothelial function, a key determinant of prognosis in heart failure with reduced ejection fraction (HFrEF), is still frequently …
Article scientifique
Evaluation of the vectorial competence of Glossina brevipalpis in the transmission of Trypanosoma congolense- savannah type, in the Matutuíne District, Maputo Province, Mozambique
Abstract African Animal Trypanosomosis (AAT) is a parasitic disease caused by trypanosome species, posing a major challenge to animal health …
Article scientifique
Continental-scale genomic surveillance of Plasmodium falciparum malaria with rapid nanopore sequencing
ABSTRACT In sub-Saharan Africa, continental-scale genomic surveillance of Plasmodium falciparum malaria is needed to track the spread of antimalarial drug …