49 publication(s) trouvée(s)
Article scientifique
Machine learning-based prediction of SARS-CoV-2 bioactivity: integrating IC50 regression and activity classification using multi-task neural networks
Abstract Accurate prediction of compound bioactivity is essential for accelerating antiviral drug discovery and reducing experimental costs. Machine learning (ML) …
Article scientifique
plsMD: a plasmid reconstruction tool from short-read assemblies
Abstract Background While whole genome sequencing has become a cornerstone of antimicrobial resistance surveillance, the reconstruction of plasmid sequences from …
Article scientifique
metaGEENOME: an integrated framework for differential abundance analysis of microbiome data in cross-sectional and longitudinal studies
BACKGROUND: Detecting biomarkers is a key objective in microbiome research, often done through 16S rRNA amplicon sequencing or shotgun metagenomic …
Article scientifique
Enhanced prediction of hemolytic activity in antimicrobial peptides using deep learning-based sequence analysis
Antimicrobial peptides (AMPs) are a promising class of antimicrobial drugs due to their broad-spectrum activity against microorganisms. However, their clinical …
Article scientifique
A multi-task graph deep learning model to predict drugs combination of synergy and sensitivity scores
Abstract Background Drug combination treatments have proven to be a realistic technique for treating challenging diseases such as cancer by …
Article scientifique
Optimizing spatio-temporal correlation structures for modeling food security in Africa: a simulation-based investigation
This study investigates the impact of spatio- temporal correlation using four spatio-temporal models: Spatio-Temporal Poisson Linear Trend Model (SPLTM), Poisson …
Article scientifique
Designing and delivering bioinformatics project-based learning in East Africa
BACKGROUND: The Eastern Africa Network for Bioinformatics Training (EANBiT) has matured through continuous evaluation, feedback, and codesign. We highlight how …
Article scientifique
Utilizing genomic signatures to gain insights into the dynamics of SARS-CoV-2 through Machine and Deep Learning techniques
The global spread of the SARS-CoV-2 pandemic, originating in Wuhan, China, has had profound consequences on both health and the …
Article scientifique
MAC-ErrorReads: machine learning-assisted classifier for filtering erroneous NGS reads
BACKGROUND: The rapid advancement of next-generation sequencing (NGS) machines in terms of speed and affordability has led to the generation …
Article scientifique
Introducing the f0% method: a reliable and accurate approach for qPCR analysis
Abstract Background qPCR is a widely used technique in scientific research as a basic tool in gene expression analysis. Classically, …
Article scientifique
SeqPredNN: a neural network that generates protein sequences that fold into specified tertiary structures
BACKGROUND: The relationship between the sequence of a protein, its structure, and the resulting connection between its structure and function, …
Article scientifique
A hybrid Stacking-SMOTE model for optimizing the prediction of autistic genes
PURPOSE: Autism spectrum disorder(ASD) is a disease associated with the neurodevelopment of the brain. The autism spectrum can be observed …
Article scientifique
Which data subset should be augmented for deep learning? a simulation study using urothelial cell carcinoma histopathology images
BACKGROUND: Applying deep learning to digital histopathology is hindered by the scarcity of manually annotated datasets. While data augmentation can …
Article scientifique
Pro-MAP: a robust pipeline for the pre-processing of single channel protein microarray data
BACKGROUND: The central role of proteins in diseases has made them increasingly attractive as therapeutic targets and indicators of cellular …
Article scientifique
HEC-ASD: a hybrid ensemble-based classification model for predicting autism spectrum disorder disease genes
PURPOSE: Autism spectrum disorder (ASD) is the most prevalent disease today. The causes of its infection may be attributed to …
Article scientifique
Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors
BACKGROUND: In most parts of the world, especially in underdeveloped countries, acquired immunodeficiency syndrome (AIDS) still remains a major cause …
Article scientifique
H3AGWAS: a portable workflow for genome wide association studies
BACKGROUND: Genome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires several …
Article scientifique
qtlXplorer: an online systems genetics browser in the Eucalyptus Genome Integrative Explorer (EucGenIE)
BACKGROUND: Affordable high-throughput DNA and RNA sequencing technologies are allowing genomic analysis of plant and animal populations and as a …
Article scientifique
Employing phylogenetic tree shape statistics to resolve the underlying host population structure
BACKGROUND: Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful …
Article scientifique
TAGOPSIN: collating taxa-specific gene and protein functional and structural information
BACKGROUND: The wealth of biological information available nowadays in public databases has triggered an unprecedented rise in multi-database search and …
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