281 publication(s) trouvée(s)
Article scientifique
Expanding the RB1 variant landscape of heritable retinoblastoma: unlocking precision oncology potential in Southern Africa
BACKGROUND: Retinoblastoma (Rb) is the most common childhood intraocular cancer, with heritable forms caused by pathogenic germline variants in the …
Article scientifique
Relative telomer length as a potential biomarker in hepatocellular carcinoma: a comparative study of HCV patients treated with direct antiviral agent
BACKGROUND: Hepatocellular carcinoma (HCC) remains a significant complication of hepatitis C virus (HCV) infection. This study investigates the potential of …
Article scientifique
Correction to: Obese mammary tumour‑bearing mice are highly sensitive to doxorubicin‑induced hepatotoxicity
Article scientifique
Correction to: Early-stage hodgkin lymphoma in Cape Town, South Africa: prognostic risk factors at diagnosis and treatment outcomes
Conclusions "…disease stages, highlights the" should be change to "…disease stages, we highlight the". Keywords"South africa" should be change to …
Article scientifique
Early-stage Hodgkin lymphoma in Cape Town, South Africa: prognostic risk factors at diagnosis and treatment outcomes
BACKGROUND: Classic Hodgkin Lymphoma (cHL) is a highly curable cancer disproportionately affecting younger patients and those with human immunodeficiency virus …
Article scientifique
Genetic insights into acute lymphoblastic leukemia: the role of MDR1 and IL18 polymorphisms in Egyptian children
BACKGROUND: The most prevalent cancer in pediatric is acute lymphoblastic leukemia (ALL). The multidrug resistance gene (MDR1) encodes the membrane …
Article scientifique
Facilitator and barrier perspectives on learning and implementing high-resolution anoscopy in Abuja, Nigeria: a qualitative study
BACKGROUND: Early detection and treatment of anal precancer via high resolution anoscopy (HRA) is paramount to prevent anal cancer, particularly …
Article scientifique
Impact of thyroid dysfunction on clinical outcome in head and neck cancer: a systematic review and meta-analysis
BACKGROUND: The influence of thyroid dysfunction on the clinical outcomes of head and neck cancer (HNC) patients remains an area …
Article scientifique
Multilevel factors associated with clinical breast examination uptake among women in the Northern Region of Ghana: a cross-sectional survey
BACKGROUND: Despite the World Health Organization's recommendation of clinical breast examination (CBE) in resource-limited settings where mammography services are unavailable, …
Article scientifique
Prevalence and factors associated with high-risk human papillomavirus infection and cervical lesions among women with HIV in Addis Ababa, Ethiopia
BACKGROUND: In Ethiopia, the Human Papillomavirus (HPV) type distribution is still not well characterized among women with Human Immunodeficiency Virus …
Article scientifique
PD1/PDL1 and TIM3/Gal9 expression in acute lymphoblastic leukemia: Gal-9 expression on leukemia stem cells as an independent prognostic parameter
The introduction of immune checkpoint inhibitors (ICI) which are designed not to activate the immune system to attack tumors but …
Article scientifique
Evaluating the anticancer properties of VAF: a novel folate-α-tocopherol conjugate against lung cancer cells
PURPOSE: In this study, a new chemical folate conjugated to α-tocopherol (VAF) is introduced. The main goal is to investigate …
Article scientifique
Predictors of survival among children and adolescents with rhabdomyosarcoma treated in a single resource-limited centre —Uganda
BACKGROUND: The treatment outcomes for children and adolescents with rhabdomyosarcoma (RMS) in low-income countries are poor. However, there is a …
Article scientifique
Unmet supportive care need and associated factors among cancer patients
INTRODUCTION: Identifying and managing unmet supportive care needs is a vital aspect of providing comprehensive healthcare to cancer patients. Planning …
Article scientifique
Evaluating cholesterol de novo synthesis biomarkers: a systematic review and meta-analysis of cancer prognosis and clinical outcomes
BACKGROUND: While systemic cholesterol levels are generally associated with cancer risk and progression in various tumors, studies of cholesterol de …
Article scientifique
Stage at diagnosis and tumor characteristics among young women and men with breast cancer, in Ethiopia and Sweden, a descriptive cross-sectional study
BACKGROUND: Breast cancer patients diagnosed in sub-Saharan Africa (SSA) are generally younger, and present with more advanced stage of disease, …
Article scientifique
Amniotic membrane promotes doxorubicin potency by suppressing SH-SY5Y neuroblastoma cell angiogenesis
BACKGROUND: Doxorubicin (DOX) remains a mainstay for neuroblastoma (NB) treatment, but side effects hamper efficacy. We previously showed that DOX …
Article scientifique
From biomarker to targeted therapy: investigating trophoblast cell-surface antigen 2 expression in triple-negative breast cancer– insights from the national cancer institute
BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior and limited treatment options, primarily due to the lack …
Article scientifique
Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma
BACKGROUND: Multiple Myeloma (MM) is a plasma cell malignancy associated with systemic and renal complications. This study evaluates the prognostic …
Article scientifique
Emerging roles of ADAM6 and PRSS1 as novel diagnostic/prognostic biomarkers for acute lymphoblastic and myeloid leukemia in adults
Abstract Background Acute leukemia is an aggressive, highly heterogeneous hematological malignancy. A Disintegrin And Metalloproteinase Domain-6 (ADAM6), a member of …
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