391 publication(s) trouvée(s)
Article scientifique
Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
VEGFR2 and FAK signaling pathways are interconnected and have synergistic effects on tumor angiogenesis, growth, and metastasis. Thus, instead of …
Article scientifique
Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors
Abstract A receptor-based pharmacophore model describing the binding features required for the multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, …
Article scientifique
N′-(Furan-2-ylmethylene)-2-hydroxybenzohydrazide and its metal complexes: synthesis, spectroscopic investigations, DFT calculations and cytotoxicity profiling
L), was synthesized characterized through various spectral studies which cleared out that the free ligand existed in keto form. The …
Article scientifique
AQbD TLC-densitometric method approach along with green fingerprint and whiteness assessment for quantifying two combined antihypertensive agents and their impurities
Preserving the environment, reducing the amount of waste resulting from chemical trials, and reducing the amount of energy consumed have …
Article scientifique
Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives
Several novel approaches to target Bcl-2 proteins and apoptotic pathways have been identified in recent years for the treatment of …
Article scientifique
Lead generation of UPPS inhibitors targeting MRSA: Using 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamic simulations
Undecaprenyl Pyrophosphate Synthase (UPPS) is a vital target enzyme in the early stages of bacterial cell wall biosynthesis. UPPS inhibitors …
Article scientifique
Tosyl-carrageenan/alginate composite adsorbent for removal of Pb2+ ions from aqueous solutions
Abstract The current study effectively designed novel cross-linked tosyl-carrageenan/alginate (Ts-Car/Alg) beads to remove Pb 2+ ions from their aqueous solutions. …
Article scientifique
Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives
Abstract Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles …
Article scientifique
Experimental and theoretical studies of the efficiency of metal–organic frameworks (MOFs) in preventing aluminum corrosion in hydrochloric acid solution
Abstract Aluminum corrosion inhibitors “{[CuI (CN)2(phen) CuII (CN)2(phen)]5H2O},(MOF1) and {[CuI(CN)2(phen)CuII(CN)2(phen)]5H2O}@TiO2 (MOF1@TiO2) were studied in one molar HCl solution”. The ML …
Article scientifique
Development of a green synchronous spectrofluorimetric technique for simultaneous determination of Montelukast sodium and Bilastine in pharmaceutical formulations
Abstract For the treatment of rhinitis and asthma, a combination of Montelukast sodium and Bilastine has just been approved. Based …
Article scientifique
Green synthesis of silver nanoparticles and its environmental sensor ability to some heavy metals
Abstract This study marks a pioneering effort in utilizing Vachellia tortilis subsp. raddiana (Savi) Kyal. & Boatwr., (commonly known as …
Article scientifique
Ecofriendly single-step HPLC and TLC methods for concurrent analysis of ternary antifungal mixture in their pharmaceutical products
Abstract Two accurate, sensitive, and selective methods for simultaneous determination of miconazole nitrate (MIC), nystatin (NYS), and metronidazole (MET) in …
Article scientifique
Smart green spectrophotometric assay of the ternary mixture of drotaverine, caffeine and paracetamol in their pharmaceutical dosage form
components; drotaverine HCl (DRT), caffeine (CAFF), and paracetamol (PAR). The three methods depend on measuring the absorbance of the studied …
Article scientifique
Development and validation of chemometric-assisted spectrophotometric models for efficient quantitation of a binary mixture of supportive treatments in COVID-19 in the presence of its toxic impurities: a comparative study for eco-friendly assessment
The use of sustainable solvents has increased significantly in recent years due to advancements in green analytical methods. The number …
Article scientifique
Smartphone based colorimetric point-of-care sensor for abused drugs: case of baclofen determination in urine
Abstract As a GABA-β receptor agonist, the central muscle relaxant Baclofen (BAC) has a potential of abuse. Unfortunately, the sense …
Article scientifique
Nano-level assay of attention-deficit/hyperactivity disorder medicament, atomoxetine by molecular-size-based resonance rayleigh scattering strategy. Employment in content uniformity, dosage form, and plasma analysis
The psychoanaleptic medication atomoxetine (ATX) is prescribed to cure attention-deficit hyperactivity syndrome. ATX works by selective prevention of norepinephrine reuptake. …
Article scientifique
Novel analytical method based on chemometric models applied to UV–Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities
The multivariate models that are used for spectral data analysis have many beneficial applications, and one of the important applications …
Article scientifique
Design, spectral, molecular modeling, antimitotic, analytical and mechanism studies of phenyl isothiocyanate Girard's T derived metal complexes
Abstract The ligand N-{[(phenyl amino) thioxomethyl] hydrazino carbonyl methyl} trimethyl ammonium chloride (PTHAC) was prepared by the refluxing phenyl isothiocyanate …
Article scientifique
Removal of Pb(II) ions by cellulose modified-LaFeO3 sorbents from different biomasses
Abstract LaFeO3 perovskite is prepared by the cellulose-modified microwave-assisted citrate method using two different biomasses as a cellulose source; rice …
Article scientifique
Utilization of carbon-coated ZrO2/Mn-Mg-Zn ferrites nanostructures for the adsorption of Cs (I) and Sr (II) from the binary system: kinetic and equilibrium studies
Abstract Carbon-coated ZrO2/Mn-Mg-Zn ferrites nanostructures (CZ-FN) have been prepared as a new inorganic sorbent to remove Cs (I) and Sr …