269 publication(s) trouvée(s)
Article scientifique
The effect of gum Arabic supplementation on cathelicidin expression in monocyte derived macrophages in mice
BACKGROUND: Antimicrobial peptides (AMPs) are important effectors of the innate defense system. Cathelicidins, (CRAMP in mouse/rat, LL-37 in human) is …
Article scientifique
In vitro anti-HIV and cytotoxic effects of pure compounds isolated from Croton macrostachyus Hochst. Ex Delile
Abstract Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In …
Article scientifique
Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities
Abstract Background Medicinal plants have been successfully used as an alternative source of drugs for the treatment of microbial diseases. …
Article scientifique
A cross-sectional study of herbal medicine use and contributing factors among pregnant women on antenatal care follow-up at Dessie Referral Hospital, Northeast Ethiopia
BACKGROUND: Herbal medicines are widely used in the world especially in developing countries. Pregnant women use herbal products to treat …
Article scientifique
Lipotropic activities of aqueous extract of Vernonia guineensis Benth. in Wistar rats fed high fat diet
BACKGROUND: Lipotropic molecules are effective therapeutic targets to counteract non-alcoholic fatty liver disease (NAFLD). Lipotropic compounds are capable of removing …
Article scientifique
In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents
BACKGROUND: Euphorbia grandicornis is widely utilized in traditional medicine for the treatment of microbial infections including sexually transmitted diseases such …
Article scientifique
Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation
BACKGROUND: Holarrhena floribunda (G.Don) T.Durand & Schinz stem bark has anecdotal use in Ghanaian folk medicine for the management of …
Article scientifique
Cytotoxicity and anti-HIV activities of extracts of the twigs of Croton dichogamus Pax
Abstract Background Acquired immunodeficiency syndrome (AIDS) is a clinical syndrome resulting from infection with human immunodeficiency virus (HIV), which causes …
Article scientifique
Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections
BACKGROUND: The antibacterial activities of aqueous leaf extracts of Moringa oleifera, Vernonia amygdalina, Azadirachta indica and Acalypha wilkesiana against multidrug …
Article scientifique
Neuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats
BACKGROUND: Though Lippia javanica (Burm.f.) Spreng antioxidant activity has been demonstrated, its effect in protecting the brain from lead (Pb)-induced …
Article scientifique
Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice
INTRODUCTION: The use of traditional medicinal plants in the management of diarrhea has long been practiced in Ethiopia. B. abyssinica …
Article scientifique
Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats
BACKGROUND: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts …
Article scientifique
Oral administration of tartrazine (E102) accelerates the incidence and the development of 7,12-dimethylbenz(a) anthracene (DMBA)-induced breast cancer in rats
BACKGROUND: Despite the considerable advances made in the treatment of cancer, it remains a global threat. Tartrazine (E102) is a …
Article scientifique
The antioxidant and anti-inflammatory effects of Carica Papaya Linn. seeds extract on CCl4-induced liver injury in male rats
Abstract Background Oxidative stress (OS) and inflammation are the central pathogenic events in liver diseases. In this study, the protective …
Article scientifique
Antitrypanosomal activity of hydromethanol extract of leaves of Cymbopogon citratus and seeds of Lepidium sativum: in-vivo mice model
Abstract Background Trypanosomiasis is one of the neglected tropical diseases of both humans and animals which decreases their productivity and …
Article scientifique
Athrixia phylicoides tea infusion (bushman tea) improves adipokine balance, glucose homeostasis and lipid parameters in a diet-induced metabolic syndrome rat model
BACKGROUND: Central obesity and insulin resistance are associated with metabolic syndrome (MetS) which is aggravated by diet and sedentary lifestyle. …
Article scientifique
Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat
Abstract Background Mucuna pruriens(L.) has been used for the treatment of several ailments in folkloric medicine. The present study therefore …
Article scientifique
Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
BACKGROUND: Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of …
Article scientifique
Anti-apoptotic effect of Buchholzia coriacea Engl. stem back extracts on AsPC-1 and mechanisms of action
ETHNOPHARMACOLOGICAL RELEVANCE: Buchholzia coriacea Engl. is popularly called wonderful cola due to its wide ethnomedicinal use for the treatment of …
Article scientifique
Herbal medicines use and associated factors among pregnant women in Debre Tabor town, north West Ethiopia: a mixed method approach
BACKGROUND: Use of herbal medicines during pregnancy has been increase in many developing and developed countries. In spite of the …