34 publication(s) trouvée(s)
Article scientifique
Induction of high numbers of Treg cells post treatment with anti-IL-2/IL-2 complex associates with alleviation of experimental psoriasis-like skin inflammation
Abstract Background Psoriasis is a prevalent autoimmune skin disorder; however, the mechanism of its pathogenesis remains fully understood. The imbalance …
Article scientifique
Correction: Predictors of change in CD4 cell count over time for HIV/AIDS patients on ART follow-up in northern Ethiopia: a retrospective longitudinal study
Article scientifique
Bioinformatics designing of an mRNA vaccine for Mokola virus (MOKV) using immunoinformatics as a secure strategy for successful vaccine development
The Mokola Virus belongs to the family Rhabdoviridae and is genotype 3 of the Lyssavirus genera. A small number of …
Article scientifique
Predictors of change in CD4 cell count over time for HIV/AIDS patients on ART follow-up in northern Ethiopia: a retrospective longitudinal study
BACKGROUND: HIV has an effect on lowering CD4 cell count, which lowers the ability to resist contamination. For patients on …
Article scientifique
Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection
Abstract Background Malaria is a life-threatening parasitic disease typically transmitted through the bite of an infected Anopheles mosquito. There is …
Article scientifique
Advanced in immunological monitoring of HIV infection: profile of immune cells and cytokines in people living with HIV-1 in Benin
BACKGROUND: Immune cells and cytokines have been linked to viremia dynamic and immune status during HIV infection. They may serve …
Article scientifique
Immune responses to P falciparum antibodies in symptomatic malaria patients with variant hemoglobin genotypes in Ghana
BACKGROUND: Haemoglobin (Hb) variants such as sickle cell trait (SCT/HbAS) play a role in protecting against clinical malaria, but little …
Article scientifique
HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection
BACKGROUND: Fishing communities surrounding Lake Victoria in Uganda have HIV prevalence of 28% and incidence rates of 5 per 100 …
Article scientifique
Higher cytotoxic activities of CD8+ T cells and natural killer cells from peripheral blood of early diagnosed lung cancer patients
INTRODUCTION: Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered …
Article scientifique
Higher plasma interleukin − 6 levels are associated with lung cavitation in drug-resistant tuberculosis
BACKGROUND: Lung cavitation is associated with heightened TB transmission and poor treatment outcomes. This study aimed to determine the relationship …
Article scientifique
Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection
BACKGROUND: Understanding the complex interactions of the immune response mediated by Mycobacterium tuberculosis and HIV co-infection is fundamental to disease …
Article scientifique
Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats
BACKGROUND: Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections …
Article scientifique
CD4, CD8 and natural killer cells are depressed in patients with alopecia areata: their association with disease activity
Abstract Background Alopecia areata (AA) is a common inflammatory disorder targeting the hair follicles leading to non-scaring hair loss. The …
Article scientifique
Analysis of multivariate longitudinal immuno-epidemiological data using a pairwise joint modelling approach
BACKGROUND: Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and …
Article scientifique
Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa
BACKGROUND: Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a primary immunodeficiency (PID) characterised by a predisposition to infection by weakly-pathogenic …
Article scientifique
Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
BACKGROUND: Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their …
Article scientifique
Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa
BACKGROUND: The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir …
Article scientifique
Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
BACKGROUND: The spread of a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in China and other countries is …
Article scientifique
Trastuzumab immunogenicity development in patients’ sera and in laboratory animals
BACKGROUND: Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns …
Article scientifique
Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection
BACKGROUND: Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective …
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