168 publication(s) trouvée(s)
Article scientifique
Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria
BACKGROUND: In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to …
Article scientifique
The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan—from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases
BACKGROUND: East Africa is home to 170 million people and prone to frequent outbreaks of viral haemorrhagic fevers and various …
Article scientifique
Clinical features of bacterial meningitis among hospitalised children in Kenya
BACKGROUND: Diagnosing bacterial meningitis is essential to optimise the type and duration of antimicrobial therapy to limit mortality and sequelae. …
Article scientifique
Hand hygiene intervention to optimise soil-transmitted helminth infection control among primary school children: the Mikono Safi cluster randomised controlled trial in northwestern Tanzania
BACKGROUND: Soil-transmitted helminth (STH) infections are highly prevalent in resource-limited countries. We assessed the effect of a combination intervention aiming …
Article scientifique
The impact of child health interventions and risk factors on child survival in Kenya, 1993–2014: a Bayesian spatio-temporal analysis with counterfactual scenarios
BACKGROUND: During the millennium development goals period, reduction in under-five mortality (U5M) and increases in child health intervention coverage were …
Article scientifique
Prevalence and predictors of vitamin D deficiency in young African children
BACKGROUND: Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to …
Article scientifique
Cost-effectiveness modelling to optimise active screening strategy for gambiense human African trypanosomiasis in endemic areas of the Democratic Republic of Congo
BACKGROUND: Gambiense human African trypanosomiasis (gHAT) has been brought under control recently with village-based active screening playing a major role …
Article scientifique
Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study
BACKGROUND: The cardiovascular health index (CVHI) introduced by the American Heart Association is a valid, accessible, simple, and translatable metric …
Article scientifique
The importance of supplementary immunisation activities to prevent measles outbreaks during the COVID-19 pandemic in Kenya
BACKGROUND: The COVID-19 pandemic has disrupted routine measles immunisation and supplementary immunisation activities (SIAs) in most countries including Kenya. We …
Article scientifique
Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa
Article scientifique
Epilepsy management in pregnant HIV+ women in sub-Saharan Africa, clinical aspects to consider: a scoping review
BACKGROUND: Since the introduction of highly active antiretroviral therapy (HAART), acquired immune deficiency syndrome (AIDS) related mortality has markedly declined. …
Article scientifique
Risk scores for predicting early antiretroviral therapy mortality in sub-Saharan Africa to inform who needs intensification of care: a derivation and external validation cohort study
BACKGROUND: Clinical scores to determine early (6-month) antiretroviral therapy (ART) mortality risk have not been developed for sub-Saharan Africa (SSA), …
Article scientifique
Platelet activation in adult HIV-infected patients on antiretroviral therapy: a systematic review and meta-analysis
BACKGROUND: Antiretroviral therapy (ART) alters platelet reactivity, and as a consequence, patients living with HIV may be at an increased …
Article scientifique
Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration
BACKGROUND: As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monitor …
Article scientifique
Machine learning approaches classify clinical malaria outcomes based on haematological parameters
BACKGROUND: Malaria is still a major global health burden, with more than 3.2 billion people in 91 countries remaining at …
Article scientifique
Response strategies for COVID-19 epidemics in African settings: a mathematical modelling study
BACKGROUND: The health impact of COVID-19 may differ in African settings as compared to countries in Europe or China due …
Article scientifique
The impact of COVID-19 control measures on social contacts and transmission in Kenyan informal settlements
Abstract Background Many low- and middle-income countries have implemented control measures against coronavirus disease 2019 (COVID-19). However, it is not …
Article scientifique
Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and transmission settings in The Gambia
Abstract Background As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission. Serological assays measuring malaria …
Article scientifique
Measuring the availability and geographical accessibility of maternal health services across sub-Saharan Africa
BACKGROUND: With universal health coverage a key component of the 2030 Sustainable Development Goals, targeted monitoring is crucial for reducing …
Article scientifique
Seasonal influenza vaccination in Kenya: an economic evaluation using dynamic transmission modelling
BACKGROUND: There is substantial burden of seasonal influenza in Kenya, which led the government to consider introducing a national influenza …