168 publication(s) trouvée(s)
Article scientifique
The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis
BACKGROUND: An effective vaccine against Bordetella pertussis was introduced into the Expanded Programme on Immunisation (EPI) by WHO in 1974, …
Article scientifique
Systems and implementation science should be part of the COVID-19 response in low resource settings
The huge strategic response to COVID-19 is, put simply, the globe’s single largest and most concentrated health service redesign effort. …
Article scientifique
A comparison of the associations between adiposity and lipids in Malawi and the United Kingdom
BACKGROUND: The prevalence of excess adiposity, as measured by elevated body mass index (BMI) and waist-hip ratio (WHR), is increasing …
Article scientifique
Mapping male circumcision for HIV prevention efforts in sub-Saharan Africa
BACKGROUND: HIV remains the largest cause of disease burden among men and women of reproductive age in sub-Saharan Africa. Voluntary …
Article scientifique
Multidrug-resistant tuberculosis surveillance and cascade of care in Madagascar: a five-year (2012–2017) retrospective study
BACKGROUND: In Madagascar, the multidrug-resistant tuberculosis (MDR-TB) surveillance programme was launched in late 2012 wherein previously treated TB cases and …
Article scientifique
Routine data for malaria morbidity estimation in Africa: challenges and prospects
BACKGROUND: The burden of malaria in sub-Saharan Africa remains challenging to measure relying on epidemiological modelling to evaluate the impact …
Article scientifique
A systematic review of changing malaria disease burden in sub-Saharan Africa since 2000: comparing model predictions and empirical observations
BACKGROUND: The most widely used measures of declining burden of malaria across sub-Saharan Africa are predictions from geospatial models. These …
Article scientifique
Caring for Africa’s sickle cell children: will we rise to the challenge?
BACKGROUND: Most of the world's sickle cell disease (SCD) burden is in Africa, where it is a major contributor to …
Article scientifique
Pharmacotherapy for hypertension in Sub-Saharan Africa: a systematic review and network meta-analysis
BACKGROUND: The highest burden of hypertension is found in Sub-Saharan Africa (SSA) with a threefold greater mortality from stroke and …
Article scientifique
Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
INTRODUCTION: Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced …
Article scientifique
Effect of tuberculosis screening and retention interventions on early antiretroviral therapy mortality in Botswana: a stepped-wedge cluster randomized trial
BACKGROUND: Undiagnosed tuberculosis (TB) remains the most common cause of HIV-related mortality. Xpert MTB/RIF (Xpert) is being rolled out globally …
Article scientifique
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic
BACKGROUND: Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 …
Article scientifique
Mapping malaria seasonality in Madagascar using health facility data
BACKGROUND: Many malaria-endemic areas experience seasonal fluctuations in case incidence as Anopheles mosquito and Plasmodium parasite life cycles respond to …
Article scientifique
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data
BACKGROUND: The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and …
Article scientifique
Estimating the burden of iron deficiency among African children
BACKGROUND: Iron deficiency (ID) is a major public health burden in African children and accurate prevalence estimates are important for …
Article scientifique
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a …
Article scientifique
Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study
BACKGROUND: In November 2011, Malawi introduced the 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant schedule. Four to 7 …
Article scientifique
Tackling the triple threats of childhood malnutrition
The term 'double burden of malnutrition' is usually interpreted in terms of the physical status of children: stunted and wasted …
Article scientifique
Does low-density lipoprotein cholesterol induce inflammation? If so, does it matter? Current insights and future perspectives for novel therapies
BACKGROUND: Dyslipidemia and inflammation are closely interrelated contributors in the pathogenesis of atherosclerosis. Disorders of lipid metabolism initiate an inflammatory …
Article scientifique
Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies
BACKGROUND: Environmental enteric dysfunction (EED) is an acquired enteropathy of the small intestine, characterized by enteric inflammation, villus blunting and …